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NEUROLOGY 2006;67:1872-1875
© 2006 American Academy of Neurology
Brief Communications

Efficacy of carbamazepine and valproate as monotherapy for early epilepsy and single seizures

A. G. Marson, MD, P. R. Williamson, PhD, S. Taylor, MSc, M. Maguire, MB, ChB, D. W. Chadwick, DM on behalf of the MESS Study Group

From the Division of Neurological Sciences (A.G.M., M.M., D.W.C.) and Centre for Medical Statistics and Health Evaluation (P.R.W., S.T.), The University of Liverpool, UK.

Address correspondence and reprint requests to Dr Marson, Division of Neurological Science, Clinical Sciences Centre for Research and Education, Lower Lane, Fazakerley, Liverpool, L9 7LJ, UK; e-mail: a.g.marson{at}liv.ac.uk

In the Multi-Centre Study of Early Epilepsy and Single Seizures (MESS), patients were randomly allocated to immediate or delayed antiepileptic drug treatment. For time to first seizure recurrence, MESS provides strong evidence of an effect for carbamazepine as monotherapy but mixed evidence of an effect for valproate.

Disclosure: The authors report no conflicts of interest.

Received December 19, 2005. Accepted in final form July 25, 2006.


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