Quasispecies evolution in general mean-field landscapes

2002 EDP Sciences
, , Citation L. Peliti 2002 EPL 57 745 DOI 10.1209/epl/i2002-00526-5

0295-5075/57/5/745

Abstract

I consider a class of fitness landscapes, in which the fitness is a function of a finite number of phenotypic "traits", which are themselves linear functions of the genotype. I show that the stationary trait distribution in such a landscape can be explicitly evaluated in a suitably defined "thermodynamic limit", which is a combination of infinite-genome and strong selection limits. These considerations can be applied in particular to identify relevant features of the evolution of promoter binding sites, in spite of the shortness of the corresponding sequences.

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10.1209/epl/i2002-00526-5