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Microcapsules and Transdermal Patch: A Comparative Approach for Improved Delivery of Antidiabetic Drug

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Abstract

Glibenclamide (GL)-loaded microcapsules (MC) and transdermal patches (TDP) were formulated and in vitro and in vivo parameters compared to find out the best route of drug administration. The formulation TDP1 having a drug–polymer ratio 1:1 showed comparatively higher GL release and better permeation across mice skin (p < 0.05). From the comparative study, it was concluded that the transdermal system of GL produced better improvement compared to oral microcapsule administration (p < 0.05). The transdermal system exhibited comparatively slow and continuous supply of GL at a desired rate to systemic circulation avoiding metabolism, which improved day-to-day glycemic control in diabetic subjects. Transdermal system of GL exhibited better control of hyperglycemia and prolonged plasma half-life by transdermal systems (9.6 ± 1.2 h) in comparison with oral microcapsule (5.84 ± 2.1 h), indicating that the drug, when administered by transdermal systems, will remain in the body for a longer period. From the glucose tolerance test, transdermal route effectively maintained the normoglycemic levels in contrast to the oral group (MC1), which produced remarkable hypoglycemia ranging from −12.6 ± 2.1% to −18 ± 2.3%. The significantly high (p < 0.05) area under the curve values observed with transdermal system (1,346.2 ± 92.3 ng ml−1 h−1) also indicate increased bioavailability of the drug from these systems compared to the oral route (829.8 ± 76.4 ng ml−1 h−1).

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Acknowledgments

This work was supported by the Siksha-O-Anusandhan University, India. The authors would like to thank Zydus Cadila Pharmaceuticals Ltd., Gujarat, India for providing the gift sample of glibenclamide for the study.

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Authors and Affiliations

  1. School of Pharmaceutical Sciences, SOA University, Bhubaneswar, 751003, India

    Manoj K. Mishra

  2. P.G. Department of Pharmaceutics, Sri Jayadev College of Pharmaceutical Sciences, Bhubaneswar, 752101, India

    Debajyoti Ray

  3. University Department of Pharmaceutical Sciences, Utkal University, Bhubaneswar, 751004, India

    Bhakti B. Barik

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  1. Manoj K. Mishra
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  2. Debajyoti Ray
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Correspondence to Manoj K. Mishra.

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Mishra, M.K., Ray, D. & Barik, B.B. Microcapsules and Transdermal Patch: A Comparative Approach for Improved Delivery of Antidiabetic Drug. AAPS PharmSciTech 10, 928–934 (2009). https://doi.org/10.1208/s12249-009-9289-z

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