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In vivo ocular availability of ketorolac following ocular instillations of aqueous, oil, and ointment formulations to normal corneas of rabbits: A technical note

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Conclusions

In vivo ocular availability of ketorolac was evaluated following ocular instillation of aqueous, oil, and ointment formulations to normal corneas of rabbits and monitoring ketorolac concentration in aqueous humor by HPLC. Compared with aqueous drop, sesame and soybean oil drops of ketorolac provided higher ocular availability followed by ophthalmic ointment. The ointment formulation provided maximum sustained effect. Ketorolac aqueous drop with BAC and EDTA improved the rate of ocular absorption though not the extent.

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Authors and Affiliations

  1. Department of Pharmaceutics, Delhi Institute of Pharmaceutical Sciences and Research, Formerly College of Pharmacy (University of Delhi), Pushp Vihar, Sector III, 110017, New Delhi, India

    Manjusha Malhotra & Dipak K. Majumdar

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  1. Manjusha Malhotra
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  2. Dipak K. Majumdar
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Correspondence to Dipak K. Majumdar.

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Published: October 24, 2005

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Malhotra, M., Majumdar, D.K. In vivo ocular availability of ketorolac following ocular instillations of aqueous, oil, and ointment formulations to normal corneas of rabbits: A technical note. AAPS PharmSciTech 6, 65 (2005). https://doi.org/10.1208/pt060365

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  • DOI: https://doi.org/10.1208/pt060365

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