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Organic–Inorganic Composites for Bone Drug Delivery

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Abstract

This review paper attempts to provide an overview in the fabrication and application of organic–inorganic based composites in the field of local drug delivery for bone. The concept of local drug delivery exists for a few decades. However, local drug delivery in bone and specially application of composites for delivery of drugs to bone is an area for potential research interest in the recent time. The advantages attained by an organic–inorganic composite when compared to its individual components include their ability to release drug, adopting to the natural environment and supporting local area until complete bone regeneration, which make them carriers of interest for local drug delivery for bone.

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Abbreviations

BG:

Bioactive glass

BMP:

Bone morphogenetic protein

CS:

Calcium sulfate

DMC:

Dimethyl carbonate

Hap:

Hydroxyapatite

PCL:

Polycaprolactone

PDLLA:

Poly (d,l-lactide)

PHBV:

Polyhydroxybutyrate-co-hydroxyvalerate

PLGA:

Polylactide-co-glycolide

PMMA:

Polymethylmethacrylate

rh:

Recombinant human

SBF:

Simulated body fluid

TCP:

Tricalcium phosphate

TGF:

Transforming growth factor

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Authors and Affiliations

  1. Department of Pharmaceutical Technology, Jadavpur University, Kolkata, 700032, India

    Chidambaram Soundrapandian & Biswanath Sa

  2. Bioceramic and Coating Division, Central Glass & Ceramic Research Institute, Raja S C Mallick Road, Kolkata, 700032, India

    Someswar Datta

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  1. Chidambaram Soundrapandian
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Soundrapandian, C., Sa, B. & Datta, S. Organic–Inorganic Composites for Bone Drug Delivery. AAPS PharmSciTech 10, 1158–1171 (2009). https://doi.org/10.1208/s12249-009-9308-0

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