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Compressed matrix core tablet as a quick/slow dual-component delivery system containing ibuprofen

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Abstract

The purpose of the present research was to produce a quick/slow biphasic delivery system for ibuprofen. A dual-component tablet made of a sustained release tableted core and an immediate release tableted coat was prepared by direct compression. Both the core and the coat contained a model drug (ibuprofen). The sustained release effect was achieved with a polymer (hydroxypropyl methylcellulose [HPMC] or ethylcellulose) to modulate the release of the drug. The in vitro drug release profile from these tablets showed the desired biphasic release behavior: the ibuprofen contained in the fast releasing component was dissolved within 2 minutes, whereas the drug in the core tablet was released at different times (⊂16 or >24 hours), depending on the composition of the matrix tablet. Based on the release kinetic parameters calculated, it can be concluded that the HPMC core was suitable for providing a constant and controlled release (zero order) for a long period of time.

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Authors and Affiliations

  1. Departmento de Tecnologia Farmacêutica, Faculdade de Farmácia, Universidade do Porto, Rua Aníbal Cunha, 164, 4050-047, Porto, Portugal

    Carla Martins Lopes, José M. Sousa Lobo & Paulo C. Costa

  2. Departmento de Tecnologia Farmacêutica, Faculdade de Farmácia, Universidade de Lisboa, Av Prof Gama Pinto, 1649-003, Lisboa, Portugal

    João F. Pinto

Authors
  1. Carla Martins Lopes
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  2. José M. Sousa Lobo
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  3. João F. Pinto
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  4. Paulo C. Costa
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Corresponding author

Correspondence to Carla Martins Lopes.

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Published: September 21, 2007

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Lopes, C.M., Sousa Lobo, J.M., Pinto, J.F. et al. Compressed matrix core tablet as a quick/slow dual-component delivery system containing ibuprofen. AAPS PharmSciTech 8, 76 (2007). https://doi.org/10.1208/pt0803076

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  • DOI: https://doi.org/10.1208/pt0803076

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