ABSTRACT
Ethosomes are vesicular nanocarriers that carry a relatively high concentration of ethanol. Ethanol is a very good permeation enhancer, conferring ethosomes with unique properties such as strong flexibility and deformability, allowing them to penetrate deeply across the skin and improve drug penetration and deposition. A crucial pre-processing tool is an ethosome, which acts as a drug delivery system. The size of ethosomes, which range from 30 nm to several microns, is smooth and malleable. As new formulations and methods have been created over time, the science of drug distribution has changed. Biodegradable polymers have been utilized in nanotechnology to make nanoparticulate systems, such as nanospheres and nanocapsules, that may cross the blood–brain barrier and penetrate particular organs, like the eye, brain, gastrointestinal tract, and urine bladder. Common ethosomes are reformulated liposomes that include phospholipids, water, and a sizable amount of ethanol.
