ABSTRACT
Nanoemulsion (NE) is getting substantial attention in the field of nutraceutical science attributed to the enhanced functionality of bioactive compounds like active molecules, theranostic molecules, nutraceuticals, vitamins, preservatives, sweeteners, and flavors by means of nanoemulsion. The thermodynamic stability, transparent nature, and protection from oxidative degradation are a few of the major advantages that fall in the list of merits of nanoemulsions. The nanometric size range with a high surface area makes NEs to bring significant changes in the prospects of encapsulated therapeutics. Therefore, a better understanding of the theories of the fabrication of NEs as well as the techniques involved in the industrial-scale development needs significant consideration. In this chapter, theories, formulation techniques, and the outcome are summarized. The pros and cons are also explained in this chapter for each methodology used in the preparation of NE. The development of the nano-sized emulsion can be alienated into two major categories, the low-energy emulsification, and the high-energy emulsification methods. In high-energy emulsification methods, high-pressure homogenization, microfluidization, and ultrasonic emulsification are illustrated systematically. The phase inversion temperature (PIT), spontaneous emulsification, phase inversion composition (PIC), and very uncommon D-phase emulsification methods are described under low-energy methods.
