ABSTRACT
This paper investigates the use of solution electrospinning to produce polycaprolactone (PCL) wound dressings and explores the role of polymer concentration and voltage on the morphological, mechanical, and biological properties of a polycaprolactone electrospun mesh. Polymer solutions were prepared with acetic acid at different concentrations (16% (w/v), 20% (w/v), and 24% (w/v)). Electrospun meshes were produced using different voltages (10 kV and 14 kV) with a constant flow rate (0.5 mL/h). Morphological observations show that the fibre diameter decreases by increasing the applied voltage, and increases by increasing PCL concentration, which leads to improved mechanical properties. Electrospun meshes were biologically assessed using human adipose-derived mesenchymal stem cells. Results showed that cells were viable on all meshes and able to proliferate.
