Advertisement
Journal of Clinical Oncology  
Search for:
Limit by:
  Browse by Subject or Issue
Home Search or Browse JCO My JCO Subscriptions Customer Service Site Map

Originally published as JCO Early Release 10.1200/JCO.2005.07.032 on February 28 2005

Journal of Clinical Oncology, Vol 23, No 16 (June 1), 2005: pp. 3676-3685
© 2005 American Society of Clinical Oncology.
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Save to my personal folders
Right arrow Download to citation manager
Right arrowRights & Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Buzdar, A. U.
Right arrow Articles by Hortobagyi, G. N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Buzdar, A. U.
Right arrow Articles by Hortobagyi, G. N.
Related Articles
Right arrowRelated Editorial

Significantly Higher Pathologic Complete Remission Rate After Neoadjuvant Therapy With Trastuzumab, Paclitaxel, and Epirubicin Chemotherapy: Results of a Randomized Trial in Human Epidermal Growth Factor Receptor 2–Positive Operable Breast Cancer

Aman U. Buzdar, Nuhad K. Ibrahim, Deborah Francis, Daniel J. Booser, Eva S. Thomas, Richard L. Theriault, Lajos Pusztai, Marjorie C. Green, Banu K. Arun, Sharon H. Giordano, Massimo Cristofanilli, Debra K. Frye, Terry L. Smith, Kelly K. Hunt, Sonja E. Singletary, Aysegul A. Sahin, Michael S. Ewer, Thomas A. Buchholz, Donald Berry, Gabriel N. Hortobagyi

From the Departments of Breast Medical Oncology, Biostatistics, Surgical Oncology, Pathology, Cardiology, and Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX

Address reprint requests to Aman U. Buzdar, MD, Department of Breast Medical Oncology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Unit 424, Houston, TX 77030; e-mail: abuzdar{at}mdanderson.org

PURPOSE: The objective of this study was to determine whether the addition of trastuzumab to chemotherapy in the neoadjuvant setting could increase pathologic complete response (pCR) rate in patients with human epidermal growth factor receptor 2 (HER2) –positive disease.

PATIENTS AND METHODS: Forty-two patients with HER2-positive disease with operable breast cancer were randomly assigned to either four cycles of paclitaxel followed by four cycles of fluorouracil, epirubicin, and cyclophosphamide or to the same chemotherapy with simultaneous weekly trastuzumab for 24 weeks. The primary objective was to demonstrate a 20% improvement in pCR (assumed 21% to 41%) with the addition of trastuzumab to chemotherapy. The planned sample size was 164 patients.

RESULTS: Prognostic factors were similar in the two groups. After 34 patients had completed therapy, the trial's Data Monitoring Committee stopped the trial because of superiority of trastuzumab plus chemotherapy. pCR rates were 25% and 66.7% for chemotherapy (n = 16) and trastuzumab plus chemotherapy (n = 18), respectively (P = .02). The decision was based on the calculation that, if study continued to 164 patients, there was a 95% probability that trastuzumab plus chemotherapy would be superior. Of the 42 randomized patients, 26% in the chemotherapy arm achieved pCR compared with 65.2% in the trastuzumab plus chemotherapy arm (P = .016). The safety of this approach is not established, although no clinical congestive heart failure was observed. A more than 10% decrease in the cardiac ejection fraction was observed in five and seven patients in the chemotherapy and trastuzumab plus chemotherapy arms, respectively.

CONCLUSION: Despite the small sample size, these data indicate that adding trastuzumab to chemotherapy, as used in this trial, significantly increased pCR without clinical congestive heart failure.

Supported in part by research grants from Genentech, Pfizer, and Bristol Myers Squibb.

Authors' disclosures of potential conflicts of interest are found at the end of this article.


Related Editorial

  • HER2 or Not HER2: That Is the Question
    Harold J. Burstein and Eric P. Winer
    JCO 2005 23: 3656-3659 [Full Text]


This article has been cited by other articles:


Home page
 The Annals of PharmacotherapyHome page
S. Srinivasan, V. Parsa, C. Y Liu, and J. A Fontana
Trastuzumab-Induced Hepatotoxicity
Ann. Pharmacother., October 1, 2008; 42(10): 1497 - 1501.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
F. Peintinger, A. U. Buzdar, H. M. Kuerer, J. A. Mejia, C. Hatzis, A. M. Gonzalez-Angulo, L. Pusztai, F. J. Esteva, S. S. Dawood, M. C. Green, et al.
Hormone receptor status and pathologic response of HER2-positive breast cancer treated with neoadjuvant chemotherapy and trastuzumab
Ann. Onc., July 29, 2008; (2008) mdn427v1.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
D. L. Rowe, T. Ozbay, L. M. Bender, and R. Nahta
Nordihydroguaiaretic acid, a cytotoxic insulin-like growth factor-I receptor/HER2 inhibitor in trastuzumab-resistant breast cancer
Mol. Cancer Ther., July 1, 2008; 7(7): 1900 - 1908.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Surg. Oncol.Home page
S. Kulkarni and D. G. Hicks
HER2-Positive Early Breast Cancer and Trastuzumab: A Surgeon's Perspective
Ann. Surg. Oncol., June 1, 2008; 15(6): 1677 - 1688.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
I. J. Dahabreh, H. Linardou, F. Siannis, G. Fountzilas, and S. Murray
Trastuzumab in the Adjuvant Treatment of Early-Stage Breast Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Oncologist, June 1, 2008; 13(6): 620 - 630.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Surg. Oncol.Home page
L. Jacobs
Positive Margins: The Challenge Continues for Breast Surgeons
Ann. Surg. Oncol., May 1, 2008; 15(5): 1271 - 1272.
[Full Text] [PDF]

Home page
 JCOHome page
E. L. Mayer and H. J. Burstein
Weighing a Dose-Dense Option for Adjuvant Chemotherapy and Trastuzumab in Early-Stage Breast Cancer
J. Clin. Oncol., March 10, 2008; 26(8): 1198 - 1200.
[Full Text] [PDF]

Home page
 Jpn J Clin OncolHome page
S.-C. Chen, H.-K. Chang, Y.-C. Lin, S. Hsueh, Y.-C. Cheung, W.-M. Leung, C.-S. Tsai, Y.-F. Lo, H.-P. Tsai, S.-C. Shen, et al.
High Pathologic Complete Response in HER 2-positive Locally Advanced Breast Cancer after Primary Systemic Chemotherapy with Weekly Docetaxel and Epirubicin
Jpn. J. Clin. Oncol., February 12, 2008; (2008) hym172v1.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
A. C. Wolff, D. Berry, L. A. Carey, M. Colleoni, M. Dowsett, M. Ellis, J. E. Garber, D. Mankoff, S. Paik, L. Pusztai, et al.
Research Issues Affecting Preoperative Systemic Therapy for Operable Breast Cancer
J. Clin. Oncol., February 10, 2008; 26(5): 806 - 813.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
E. Azambuja, V. Durbecq, D. D. Rosa, M. Colozza, D. Larsimont, M. Piccart-Gebhart, and F. Cardoso
HER-2 overexpression/amplification and its interaction with taxane-based therapy in breast cancer
Ann. Onc., February 1, 2008; 19(2): 223 - 232.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
B. R.J. H. Bird and S. M. Swain
Cardiac Toxicity in Breast Cancer Survivors: Review of Potential Cardiac Problems
Clin. Cancer Res., January 1, 2008; 14(1): 14 - 24.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
S. Dawood, K. Broglio, S.-W. Kau, R. Islam, W. F. Symmans, T. A. Buchholz, S. E. McGuire, F. Meric-Bernstam, M. Cristofanilli, G. N. Hortobagyi, et al.
Prognostic Value of Initial Clinical Disease Stage After Achieving Pathological Complete Response
Oncologist, January 1, 2008; 13(1): 6 - 15.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
L. Harris, H. Fritsche, R. Mennel, L. Norton, P. Ravdin, S. Taube, M. R. Somerfield, D. F. Hayes, and R. C. Bast Jr
American Society of Clinical Oncology 2007 Update of Recommendations for the Use of Tumor Markers in Breast Cancer
J. Clin. Oncol., November 20, 2007; 25(33): 5287 - 5312.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Surg. Oncol.Home page
A. Haid, M. Knauer, S. Dunzinger, Z. Jasarevic, R. Koberle-Wuhrer, A. Schuster, M. Toeppker, B. Haid, E. Wenzl, and F. Offner
Intra-operative Sonography: A Valuable Aid During Breast-Conserving Surgery for Occult Breast Cancer
Ann. Surg. Oncol., November 1, 2007; 14(11): 3090 - 3101.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
L. Arnould, P. Arveux, J. Couturier, M. Gelly-Marty, C. Loustalot, F. Ettore, C. Sagan, M. Antoine, F. Penault-Llorca, B. Vasseur, et al.
Pathologic Complete Response to Trastuzumab-Based Neoadjuvant Therapy Is Related to the Level of HER-2 Amplification
Clin. Cancer Res., November 1, 2007; 13(21): 6404 - 6409.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
J. C. Boughey, R. J. Gonzalez, E. Bonner, and H. M. Kuerer
Current Treatment and Clinical Trial Developments for Ductal Carcinoma In Situ of the Breast
Oncologist, November 1, 2007; 12(11): 1276 - 1287.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
W.-C. Lin and J.-H. Chen
Urinary Bladder Metastasis From Breast Cancer With Heterogeneic Expression of Estrogen and Progesterone Receptors
J. Clin. Oncol., September 20, 2007; 25(27): 4308 - 4310.
[Full Text] [PDF]

Home page
 Ann OncolHome page
O Camara, M Rengsberger, A Egbe, A Koch, M Gajda, U Hammer, C Jorke, C Rabenstein, M Untch, and K Pachmann
The relevance of circulating epithelial tumor cells (CETC) for therapy monitoring during neoadjuvant (primary systemic) chemotherapy in breast cancer
Ann. Onc., September 1, 2007; 18(9): 1484 - 1492.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
J. R. Carver, C. L. Shapiro, A. Ng, L. Jacobs, C. Schwartz, K. S. Virgo, K. L. Hagerty, M. R. Somerfield, D. J. Vaughn, and for the ASCO Cancer Survivorship Expert Panel
American Society of Clinical Oncology Clinical Evidence Review on the Ongoing Care of Adult Cancer Survivors: Cardiac and Pulmonary Late Effects
J. Clin. Oncol., September 1, 2007; 25(25): 3991 - 4008.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
F. Peintinger, K. Anderson, C. Mazouni, H. M. Kuerer, C. Hatzis, F. Lin, G. N. Hortobagyi, W. F. Symmans, and L. Pusztai
Thirty-Gene Pharmacogenomic Test Correlates with Residual Cancer Burden after Preoperative Chemotherapy for Breast Cancer
Clin. Cancer Res., July 15, 2007; 13(14): 4078 - 4082.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
B. P. Coudert, R. Largillier, L. Arnould, P. Chollet, M. Campone, D. Coeffic, F. Priou, J. Gligorov, X. Martin, V. Trillet-Lenoir, et al.
Multicenter Phase II Trial of Neoadjuvant Therapy With Trastuzumab, Docetaxel, and Carboplatin for Human Epidermal Growth Factor Receptor-2 Overexpressing Stage II or III Breast Cancer: Results of the GETN(A)-1 Trial
J. Clin. Oncol., July 1, 2007; 25(19): 2678 - 2684.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
G. Agrawal, J. H. Chen, C. H. Baick, A. E. Chen, R. S. Mehta, O. Nalcioglu, and M.-Y. Su
Pathological Complete Response in Triple Negative Poorly Differentiated Invasive Ductal Breast Carcinoma Detected During Pregnancy
J. Clin. Oncol., June 20, 2007; 25(18): 2618 - 2620.
[Full Text] [PDF]

Home page
 Ann OncolHome page
C Natoli, E Cianchetti, N Tinari, D Angelucci, A Grassadonia, M Zilli, C Ficorella, E Ricevuto, S Grossi, M De Tursi, et al.
A phase II study of dose-dense epirubicin plus cyclophosphamide followed by docetaxel plus capecitabine and pegfilgrastim support as preoperative therapy for patients with stage II, IIIA breast cancer
Ann. Onc., June 1, 2007; 18(6): 1015 - 1020.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
G. G. Steger, A. Galid, M. Gnant, B. Mlineritsch, A. Lang, C. Tausch, M. Rudas, R. Greil, C. Wenzel, C. F. Singer, et al.
Pathologic Complete Response With Six Compared With Three Cycles of Neoadjuvant Epirubicin Plus Docetaxel and Granulocyte Colony-Stimulating Factor in Operable Breast Cancer: Results of ABCSG-14
J. Clin. Oncol., May 20, 2007; 25(15): 2012 - 2018.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
L. A. Carey, E. C. Dees, L. Sawyer, L. Gatti, D. T. Moore, F. Collichio, D. W. Ollila, C. I. Sartor, M. L. Graham, and C. M. Perou
The Triple Negative Paradox: Primary Tumor Chemosensitivity of Breast Cancer Subtypes
Clin. Cancer Res., April 15, 2007; 13(8): 2329 - 2334.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
S. A. Limentani, A. M. Brufsky, J. K. Erban, M. Jahanzeb, and D. Lewis
Phase II Study of Neoadjuvant Docetaxel, Vinorelbine, and Trastuzumab Followed by Surgery and Adjuvant Doxorubicin Plus Cyclophosphamide in Women With Human Epidermal Growth Factor Receptor 2-Overexpressing Locally Advanced Breast Cancer
J. Clin. Oncol., April 1, 2007; 25(10): 1232 - 1238.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
F. Penault-Llorca, C. Abrial, M.-A. Mouret-Reynier, I. Raoelfils, X. Durando, M. Leheurteur, P. Gimbergues, J. Tortochaux, H. Cure, and P. Chollet
Achieving Higher Pathological Complete Response Rates in HER-2-Positive Patients With Induction Chemotherapy Without Trastuzumab in Operable Breast Cancer
Oncologist, April 1, 2007; 12(4): 390 - 396.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
E. Suzuki, R. Niwa, S. Saji, M. Muta, M. Hirose, S. Iida, Y. Shiotsu, M. Satoh, K. Shitara, M. Kondo, et al.
A Nonfucosylated Anti-HER2 Antibody Augments Antibody-Dependent Cellular Cytotoxicity in Breast Cancer Patients
Clin. Cancer Res., March 15, 2007; 13(6): 1875 - 1882.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
L. N. Harris, F. You, S. J. Schnitt, A. Witkiewicz, X. Lu, D. Sgroi, P. D. Ryan, S. E. Come, H. J. Burstein, B.-A. Lesnikoski, et al.
Predictors of Resistance to Preoperative Trastuzumab and Vinorelbine for HER2-Positive Early Breast Cancer
Clin. Cancer Res., February 15, 2007; 13(4): 1198 - 1207.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
K. C. Lee, B. A. Moffat, A. F. Schott, R. Layman, S. Ellingworth, R. Juliar, A. P. Khan, M. Helvie, C. R. Meyer, T. L. Chenevert, et al.
Prospective Early Response Imaging Biomarker for Neoadjuvant Breast Cancer Chemotherapy
Clin. Cancer Res., January 15, 2007; 13(2): 443 - 450.
[Abstract] [Full Text] [PDF]

Home page
 Jpn J Clin OncolHome page
C. Shimizu, M. Ando, T. Kouno, N. Katsumata, and Y. Fujiwara
Current Trends and Controversies over Pre-operative Chemotherapy for Women with Operable Breast Cancer
Jpn. J. Clin. Oncol., January 3, 2007; (2007) hyl122v1.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
A. U. Buzdar, V. Valero, N. K. Ibrahim, D. Francis, K. R. Broglio, R. L. Theriault, L. Pusztai, M. C. Green, S. E. Singletary, K. K. Hunt, et al.
Neoadjuvant Therapy with Paclitaxel followed by 5-Fluorouracil, Epirubicin, and Cyclophosphamide Chemotherapy and Concurrent Trastuzumab in Human Epidermal Growth Factor Receptor 2-Positive Operable Breast Cancer: An Update of the Initial Randomized Study Population and Data of Additional Patients Treated with the Same Regimen
Clin. Cancer Res., January 1, 2007; 13(1): 228 - 233.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
C. J. Poole, H. M. Earl, L. Hiller, J. A. Dunn, S. Bathers, R. J. Grieve, D. A. Spooner, R. K. Agrawal, I. N. Fernando, A. M. Brunt, et al.
Epirubicin and Cyclophosphamide, Methotrexate, and Fluorouracil as Adjuvant Therapy for Early Breast Cancer
N. Engl. J. Med., November 2, 2006; 355(18): 1851 - 1862.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Surg. Oncol.Home page
F. Peintinger, H. M. Kuerer, K. Anderson, J. C. Boughey, F. Meric-Bernstam, S. E. Singletary, K. K. Hunt, G. J. Whitman, T. Stephens, A. U. Buzdar, et al.
Accuracy of the Combination of Mammography and Sonography in Predicting Tumor Response in Breast Cancer Patients After Neoadjuvant Chemotherapy
Ann. Surg. Oncol., November 1, 2006; 13(11): 1443 - 1449.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
F. Meric-Bernstam and M.-C. Hung
Advances in targeting human epidermal growth factor receptor-2 signaling for cancer therapy.
Clin. Cancer Res., November 1, 2006; 12(21): 6326 - 6330.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
V. Guarneri, D. J. Lenihan, V. Valero, J.-B. Durand, K. Broglio, K. R. Hess, L. B. Michaud, A. M. Gonzalez-Angulo, G. N. Hortobagyi, and F. J. Esteva
Long-Term Cardiac Tolerability of Trastuzumab in Metastatic Breast Cancer: The M.D. Anderson Cancer Center Experience
J. Clin. Oncol., September 1, 2006; 24(25): 4107 - 4115.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
D. F. Hayes and M. H. Picard
Heart of Darkness: The Downside of Trastuzumab
J. Clin. Oncol., September 1, 2006; 24(25): 4056 - 4058.
[Full Text] [PDF]

Home page
 The OncologistHome page
A. M. Gonzalez-Angulo, G. N. Hortobagyi, and F. J. Esteva
Adjuvant Therapy with Trastuzumab for HER-2/neu-Positive Breast Cancer
Oncologist, September 1, 2006; 11(8): 857 - 867.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
A. Vocaturo, F. Novelli, M. Benevolo, G. Piperno, F. Marandino, A. M. Cianciulli, R. Merola, R. P. Donnorso, I. Sperduti, S. Buglioni, et al.
Chromogenic In Situ Hybridization to Detect HER-2/neu Gene Amplification in Histological and ThinPrep(R)-Processed Breast Cancer Fine-Needle Aspirates: A Sensitive and Practical Method in the Trastuzumab Era
Oncologist, September 1, 2006; 11(8): 878 - 886.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
S. Chia, M. Clemons, L.-A. Martin, A. Rodgers, K. Gelmon, G. R. Pond, and L. Panasci
Pegylated Liposomal Doxorubicin and Trastuzumab in HER-2 Overexpressing Metastatic Breast Cancer: A Multicenter Phase II Trial
J. Clin. Oncol., June 20, 2006; 24(18): 2773 - 2778.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
I. Sachelarie, M. L. Grossbard, M. Chadha, S. Feldman, M. Ghesani, and R. H. Blum
Primary Systemic Therapy of Breast Cancer
Oncologist, June 1, 2006; 11(6): 574 - 589.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
F. Montemurro, G. Valabrega, M. Aglietta, H. Joensuu, P. Bono, and P. Kellokumpu-Lehtinen
Trastuzumab Treatment in Breast Cancer
N. Engl. J. Med., May 18, 2006; 354(20): 2186 - 2186.
[Full Text] [PDF]

Home page
 JCOHome page
M. Kaufmann, G. N. Hortobagyi, A. Goldhirsch, S. Scholl, A. Makris, P. Valagussa, J.-U. Blohmer, W. Eiermann, R. Jackesz, W. Jonat, et al.
Recommendations From an International Expert Panel on the Use of Neoadjuvant (Primary) Systemic Treatment of Operable Breast Cancer: An Update
J. Clin. Oncol., April 20, 2006; 24(12): 1940 - 1949.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
J. Hurley, P. Doliny, I. Reis, O. Silva, C. Gomez-Fernandez, P. Velez, G. Pauletti, J. E. Powell, M. D. Pegram, and D. J. Slamon
Docetaxel, Cisplatin, and Trastuzumab As Primary Systemic Therapy for Human Epidermal Growth Factor Receptor 2-Positive Locally Advanced Breast Cancer
J. Clin. Oncol., April 20, 2006; 24(12): 1831 - 1838.
[Abstract] [Full Text] [PDF]

Home page
 Am J Health Syst PharmHome page
K. L. Kabe and J. M. Kolesar
Role of trastuzumab in adjuvant therapy for locally invasive breast cancer
Am. J. Health Syst. Pharm., March 15, 2006; 63(6): 527 - 533.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Surg. Oncol.Home page
D. H. Roukos, E. Paraskevaidis, and A. M. Kappas
Surgery in the Era of Gene Expression Profiling-Based Prediction and Individualized, Neoadjuvant Breast Cancer Therapy: The Beginning of the End?
Ann. Surg. Oncol., March 1, 2006; 13(3): 433 - 435.
[Full Text] [PDF]

Home page
 Cancer Res.Home page
H. Fiegl, S. Millinger, G. Goebel, E. Muller-Holzner, C. Marth, P. W. Laird, and M. Widschwendter
Breast Cancer DNA Methylation Profiles in Cancer Cells and Tumor Stroma: Association with HER-2/neu Status in Primary Breast Cancer
Cancer Res., January 1, 2006; 66(1): 29 - 33.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
R. Rouzier, L. Pusztai, S. Delaloge, A. M. Gonzalez-Angulo, F. Andre, K. R. Hess, A. U. Buzdar, J.-R. Garbay, M. Spielmann, M.-C. Mathieu, et al.
Nomograms to Predict Pathologic Complete Response and Metastasis-Free Survival After Preoperative Chemotherapy for Breast Cancer
J. Clin. Oncol., November 20, 2005; 23(33): 8331 - 8339.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
M. S. Ewer, M. T. Vooletich, J.-B. Durand, M. L. Woods, J. R. Davis, V. Valero, and D. J. Lenihan
Reversibility of Trastuzumab-Related Cardiotoxicity: New Insights Based on Clinical Course and Response to Medical Treatment
J. Clin. Oncol., November 1, 2005; 23(31): 7820 - 7826.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
A. Berruti, D. Generali, M. P. Brizzi, M. Ardine, L. Dogliotti, and A. Bottini
Is Pathologic Complete Response a Valid Surrogate Parameter of Treatment Efficacy in HER2 Positive Breast Cancer Patients Undergoing Primary Chemotherapy Plus Trastuzamab?
J. Clin. Oncol., November 1, 2005; 23(31): 8130 - 8131.
[Full Text] [PDF]

Home page
 JCOHome page
M. S. Ahluwalia and H. A. Daw
Neoadjuvant Therapy With Trastuzumab, Paclitaxel and Epirubicin for HER-2-Positive Operable Breast Cancer
J. Clin. Oncol., October 20, 2005; 23(30): 7759 - 7760.
[Full Text] [PDF]

Home page