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Genome Duplication-Driven Evolution of Gene Families: Insights from the Formation of the Insulin Family
Department of Neuroscience, Uppsala University, Uppsala, Sweden
Address for correspondence: Finn Hallböök, Department of Neuroscience, Unit of Developmental Neuroscience, Uppsala University, Biomedical Center, Box 587, S-751 23 Uppsala, Sweden. Voice: +46-18-471-4944; fax: +46-18-55-90-17. finn.hallbook{at}neuro.uu.se www.mun.neuro.uu.se/indexeng.html
The aim of this study was to outline the sequence of events that gave rise to the members of the insulin gene family in chordates. As part of our research, we looked for the chromosomal localization of insulin family members in the human genome.
Key Words: insulin • IGF • relaxin • gene duplication • paralogous region • 2R hypothesis
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