Journal of Lipid Research
Volume 53, Issue 2, February 2012, Pages 300-310
Research ArticlesDiabetes-induced myelin abnormalities are associated with an altered lipid pattern: protective effects of LXR activation
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open access
diabetic neuropathy
liver X receptor
myelin composition
peripheral nerve
sterol-regulatory element binding factor-1c
fatty acid synthesis
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This work was supported by a Giovanni Armenise-Harvard Foundation Career Development Grant (NM).
The online version of this article (available at http://www.jlr.org) contains supplementary data in the form of four figures.
- DPN
diabetic peripheral neuropathy
- GSL
glycosphingolipid
- IS
internal standard
- LXR
liver X receptor
- P0
myelin protein zero
- PC
phosphatidyl choline
- PE
phosphatidyl ethanolamine
- PI
phosphatidyl inositol
- PMP22
peripheral myelin protein 22
- PS
phosphatidyl serine
- SCD-1
stearoyl-CoA desaturase-1
- SCD-2
stearoyl-CoA desaturase-2
- SM
sphingomyelin
- SREBF-1c
sterol-regulatory element binding factor-1c
- STZ
streptozotocin
- Sulf
sulphatides
- TEM
transmission electron microscopy
Abbreviations:
- 1
G. Cermenati and F. Abbiati contributed equally to this work.
© 2012 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology.