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Concurrent validity study of QuickDASH with respect to DASH in patients with traumatic upper extremity amputation
BMC Musculoskeletal Disorders volume 25, Article number: 86 (2024)
Abstract
Background
The Disability of the Arm, Shoulder and Hand Outcome Measure (DASH) is a validated patient-reported outcome measure (PROM) for many upper extremity musculoskeletal disorders. In patients with severe traumatic conditions, limited evidence exists regarding the equivalence between DASH and its shortened version, QuickDASH, which is more feasible in clinical practice. The rationale of this study was to analyze the concurrent validity of QuickDASH with respect to DASH in patients with traumatic upper extremity amputation.
Methods
This study is based on a consecutive cohort of traumatic upper extremity amputation patients treated with replantation or revision (completion) amputation at Tampere University Hospital between 2009 and 2019. We estimated the concurrent validity of QuickDASH with respect to DASH by correlation coefficients, mean score differences, Bland–Altman plots, and distribution density. Additionally, we assessed internal reliability with Cronbach’s alpha coefficients and item-total correlations.
Results
We found a very strong linear correlation between DASH and QuickDASH scores (r = 0.97 [CI 95% 0.97–0.98], p < 0.001). The mean difference between DASH and QuickDASH was minor (MD = -1, SD 4 [CI95% from -1 to 0] p = 0.02). The mean sub-score for the activity domain was higher for QuickDASH than DASH (MD = -3 [CI95% from -4 to -3] p < 0.000) and lower for the symptom domain (MD = 7 [CI95% from 6 to 9] p < 0.000). The Bland and Altman plot showed good agreement between DASH and QuickDASH scores, but there was measurement error in QuickDASH with high scores (r = -0.20, [CI95% from -0.31 to -0.09], p = 0.001).
Conclusion
QuickDASH demonstrates higher total scores than the full DASH and emphasizes rating of activity over symptoms. Still, on average the differences in total scores are likely less than the MCID of DASH, and consequently, this study shows that QuickDASH can be recommended instead of the full DASH when assessing a traumatic condition.
Trial registration
Retrospectively registered.
Introduction
The Disability of the Arm, Shoulder and Hand Outcome Measure (DASH) is a validated and well-established patient-reported outcome measure (PROM) for upper extremity physical disability and symptoms [1, 2]. DASH contains 30 items that evaluate disability and symptoms using a 5-step Likert scale (raw score from 1 to 5). The raw scores from each item’s score are transformed to a final score between 0 to 100, where a higher score indicates more disability and symptoms. To make the assessment more feasible, a shorter version (the QuickDASH) was created, which includes 11 items from the full DASH [3].
PROMs are generally considered the most important assessments after surgical interventions, particularly in musculoskeletal disorders [4,5,6]. Previous concurrent validation studies have shown a high equivalence between the original DASH and the QuickDASH scores in patients with non-traumatic upper extremity muscle disorders [7,8,9,10]. To our knowledge, there are only a few studies which have included some patients with traumatic disorders (upper extremity fractures) [11,12,13,14]. Based on previous reports, the DASH is considered to be an appropriate outcome for assessment after upper extremity amputations injuries [15,16,17]. The QuickDASH has been used for assessments in patients with upper extremity amputations [18,19,20], despite that there is no evidence of equivalence between the DASH and the QuickDASH in patients with severe traumatic injuries.
The primary aim of this study was to assess the concurrent validity of the QuickDASH with respect to the DASH in participants with traumatic upper extremity amputation. Secondary goals were to evaluate the cross-sectional validity and internal reliability between the DASH and the QuickDASH.
Methods
Study design and setting
This concurrent validity study includes a consecutive cohort of participants with traumatic upper extremity amputation who underwent replantation or revision amputation in Tampere University Hospital between 2009 and 2019. Data used in this present study are from the clinical studies of these patients.
Participants and study size
The inclusion criterion was a traumatic upper extremity amputation that caused a fracture or exarticulation in the upper limb with loss of the circulation distal to the injury, excluding single-finger amputations. Participants who had not completed all the DASH items were excluded. There were no further exclusion criteria. The minimum follow-up time was 18 months (1.5 years). During the research period, a total of 372 participants met the inclusion. One participant (1/372) provided an incomplete answer for the DASH, and an additional 79 (79/372) did not respond. Resulting in a total of 292 (292/372, response rate 78%) participants included in the analysis for this study. The characteristics of the participants are presented in Table 1. Patients were sorted according to injury level: 1) distal to the carpus joint and 2) proximal to or through the carpus.
Variables
Participants were asked to complete the validated Finnish translation of the DASH [21]. The full DASH has 30 items, while the QuickDASH includes 11 of them. All items are rated on a 5-step Likert scale [1, 3]. The optional work or leisure time domains of the DASH were not included in this study. After the participants had completed the full DASH, we calculated both the DASH and the QuickDASH scores, similarly as in previous validation studies [9, 11, 22]. To calculate a standardized score between 0 and 100, the full DASH requires a minimum of 27 completed items, while the QuickDASH requires a minimum of 10 completed items [23]. We also separately calculated raw scores for the activity and symptom items as separate domains (DASH questions 1–23 and 24–30, and QuickDASH questions 1–8 and 9–11, respectively). To calculate sub-scores for the activity and symptom domains, it is required that 90% of the items in each domain is completed: QuickDASH (7/8 for activity and 3/3 for symptoms) and DASH (22/24 for activity and for 5/6 symptoms) [10, 24]. The minimum clinically important difference (MCID) is estimated to 10 points (95% confidence interval [CI] from 7 to 14) for DASH [22] and to 14 points (95% confidence interval [CI] from 8 to 20) for QuickDASH [25].
For cross-sectional validation analyses, we used health-related quality of life by EQ-5D-5L index [26] (range from -0.62 to 1.0 with the Danish parameters, where -0.62 and 1.0 represent the worst and best health statuses possible), and EQ VAS (visual analog scale from 0; the worst imaginable health state to 100; the best imaginable health state); cold intolerance by the Cold Intolerance Symptom Severity (CISS) questionnaire (scale from 4 to 100 points, where a higher number indicates worse symptoms) [27] and global rating of upper extremity function on a numeric rating scale (NRS) from 0 to 10 (0 worst, 10 best). The outcomes used for cross-sectional validation were collected simultaneously from the participants with the DASH responses, chosen to cover various aspects of disability associated with severe post-traumatic conditions.
Statistics
We used Pearson’s correlations, comparison of means (mean difference, MD) and the Bland–Altman analysis, a statistical method used to assess the agreement between two different instruments [28], to evaluate differences between the DASH and the QuickDASH scores. MD was calculated by subtracting the QuickDASH score from the DASH score. Cross-sectional validity was evaluated by the Pearson’s correlations between both DASH versions and the secondary outcomes. We used density plots to visualize the distribution of variables based on their density. Reliability (internal consistency and homogeneity) was analyzed with Cronbach’s alpha coefficients and item-total correlation (ITC), which describe the association of individual items with the mean of all other items, indicating the item validity in a questionnaire. An acceptable range for item-total correlation (ITC) in a multidimensional questionnaire is between 0.2 and 0.4 [29].
Continuous outcomes were presented as mean and standard deviation (SD). We used the paired t-test to compare mean DASH and QuickDASH scores and sub domain scores. The association between the two scores for each patient was measured using Pearson’s correlations and coefficients interpreted as follows: 0 to 0.19 as very weak, 0.20 to 0.39 as weak, 0.40 to 0.59 as moderate, 0.60 to 0.79 as strong, and 0.80 to 1 as very strong [30]. We set the significance level at α < 0.05.
Results
We found a strong linear correlation between DASH and QuickDASH scores; r = 0.97 (CI 95% 0.97–0.98, p < 0.001) (Fig. 1). The comparisons between mean DASH and QuickDASH scores show that the QuickDASH scores were slightly higher for the total group of participants and for participants with an injury level proximal to the carpus (Table 2). The mean sub-score for the activity domain was higher for QuickDASH than DASH and lower for the symptom domain (Table 3).
The Bland and Altman plot (Fig. 2) showed good agreement between DASH and QuickDASH scores and most score differences (MD = -1, SD 4 [CI95% from -1 to 0] p = 0.02) were between the agreement limits (-0.6 ± 8.8 points). Absolute differences of 10 points or more were observed in 5% of patients (15/292), with score differences ranging from 11 to -17. The variance of differences was wider for higher scores, as indicated by correlation between the differences in DASH and QuickDASH scores and mean of DASH and QuickDASH (r = -0.20, [CI95% from -0.31 to -0.09], p = 0.001). Correlations between other PROM and the DASH and QuickDASH scores did not differ, indicating high cross-sectional validity (Table 4). The density distribution of the DASH and the QuickDASH scores indicated similar spreading of scores within the group of participants and a floor effect for both instruments in the group of participants with distal amputations (Fig. 3).
Both DASH instruments had good internal reliability: Cronbach’s alpha value was 0.97 for the DASH and 0.92 for the QuickDASH. Item-total correlations (ITCs) for QuickDASH ranged from 0.55 to 0.79 and for DASH from 0.51 to 0.85. Of the five items with the highest ITCs in this study (DASH items 7,8,14,18, and 23), QuickDASH included all but one (item 8) (Table 5).
Discussion
To test the concurrent validity between DASH and QuickDASH in traumatic musculoskeletal disorders, we evaluated DASH and QuickDASH scores after traumatic upper extremity amputation. Our study shows very strong correlations between the QuickDASH and DASH scores. Mean QuickDASH scores were higher than DASH scores, in particular in participants with amputations proximal to the carpus, but this difference was likely too small to be clinically meaningful. In addition, the mean sub-score for the functional disability domain was higher, and the mean sub-score for the symptoms domain was lower than for the full DASH, which means that QuickDASH overestimates functional disability and underestimates symptoms compared to DASH. QuickDASH showed good cross-sectional validity with other outcomes, similar to the full DASH. Our results support using the more feasible QuickDASH instead of DASH in patients with a severe traumatic condition, such as upper limb amputations.
We used the validated Finnish translation of the DASH [21], allowing us to generalize the results to all validated DASH translations. There is a potential source of bias related to our extraction of the QuickDASH items from the full DASH because we don’t know if the participants would have answered differently if they had completed solely the 11 items in the QuickDASH. We have not been able to address this bias, and we regard this as the major limitation of our study. We do, however, not regard this potential bias as disqualifying for our findings, but our results must be interpreted in relation to this aspect. The extraction approach, however, has been used in similar QuickDASH concurrent validation studies [7, 9, 11] and the wording of QuickDASH questions is exactly the same as in the full DASH. Another limitation is that our study was conducted at a single center and cultural factors, such as how participants emphasize functional disability over symptoms, may influence responses and limit the generalizability of the findings worldwide. Still, we had a relatively large sample size which decreased the uncertainty of results. In addition, our cohort included participants with a wide range of injury severity, from single thumb amputation to amputation proximal to the elbow, with a correspondingly wide range in DASH and QuickDASH scores.
The correlation between the DASH and the QuickDASH total scores was very strong in our study. It was our hypothesis, because QuickDASH questions are a carefully selected subset of the original DASH [9], and our study results on traumatic injury participants are in agreement with previous validation studies on other conditions [7,8,9,10,11,12,13,14]. We observed an overall slightly higher mean QuickDASH score than DASH score and previous studies have suggested similar findings on the mean score difference (from 1 to 5 points) [7,8,9,10,11,12,13,14] with upper extremity disorders. However, the mean difference in scores between DASH and QuickDASH was smaller than MCID, but nevertheless, 5% of patients had an absolute score difference equal to or higher than the MCID of DASH. The Bland and Altman analysis indicated generally good agreement between DASH and QuickDASH scores but showed that greater scores were associated with a wider variance of differences. This finding indicates greater uncertainty with QuickDASH in patients with more severe disabilities and symptoms.
The DASH is regarded as a suitable measure for evaluating outcomes following upper extremity amputation injuries [15,16,17]. Our study showed a floor effect with distal amputations, but it was less evident in proximal amputations, in which DASH scores distribution was closer to normal distribution shape. The floor effect of DASH with distal amputations may limit the sensitivity of the DASH to detect differences in patients who have only minor disability. Still, the moderate to strong correlations between the Quick-DASH or the DASH and secondary outcomes (EQ-5D-5L index, EQ-5D VAS, CISS, and NRS rating of function) indicate that both DASH instruments assess meaningful outcomes for patients after a traumatic upper extremity amputation.
Good Cronbach’s alpha values for both the Quick-DASH and the DASH indicate high internal consistency and this finding aligns with the previous studies [7, 10, 13, 14]. The QuickDASH showed consistently lower ITCs, which is in line with a previous report [7, 10]. However, the QuickDASH included four of the five items with the highest ITC in full DASH. This finding supports the developers’ statement that QuickDASH comprises the most important questions of the DASH for assessing upper extremity disability also after a severe traumatic injury.
This study demonstrates the usefulness of QuickDASH in patients with severe traumatic disorders. The instrument is less burdensome for both patients and assessors while validity is maintained. It is important to notice the measurement error related to higher scores, and different proportions of activity and symptoms assessment when compared with full DASH. However, on average the differences in total scores are likely less than the MCID of DASH or QuickDASH, and consequently, this study supports the recommendation to use QuickDASH instead of the full DASH when assessing traumatic conditions.
Availability of data and materials
The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.
Abbreviations
- DASH:
-
The Disability of the Arm, Shoulder and Hand Outcome Measure
- QuickDASH:
-
The Shortened Disability of the Arm, Shoulder and Hand Outcome Measure
- EQ-5D-5L index:
-
The EuroQol EQ-5D-5L index value
- EQ VAS:
-
The EuroQol EQ-5D-5L health state with visual analogy scale
- CISS:
-
The Cold Intolerance Symptom Severity
- NRS:
-
Numeric pain rating scale
- MCID:
-
Minimal clinically important difference
- ITCs:
-
Item-total correlations
- MD:
-
Mean difference
- CI:
-
Confidence interval
- r:
-
Pearsons correlation coefficient
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Funding
Open access funding provided by Tampere University (including Tampere University Hospital). The institution of one or more of the authors (JP and JJ) has received, during the study period, partial funding from Tampere University Hospital (MJ006P).
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JP and JJ designed the study, analyzed the data, and drafted the manuscript. JP, IS, and JJ contributed to the interpretation of the results, revised the manuscript and approved the final submission.
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The study permit was granted (ID Number R19557) by Tays Research Service, Tampere University Hospital, Tampere, Finland, which is the legal research authority and reviews all research permit applications, regardless whether or not a study needs an Ethical Committee approval before a research permit. This study was completed in accordance with the Helsinki Declaration as revised in 2013. All data in this methodological study was collected from a retrospective cohort study that aimed to investigate outcomes after upper extremity amputation injuries, not an interventional or experimental trial. Furthermore, our study is a diagnostic study (not a clinical trial); therefore, it is not registered. Patients who were willing to participate completed the patient-reported outcome measures and a study-specific questionnaire. Written informed consent was waived by Tays Research Service, Tampere University Hospital, Tampere, Finland, because it is not needed for this type of study.
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Pyörny, J., Sletten, I.N. & Jokihaara, J. Concurrent validity study of QuickDASH with respect to DASH in patients with traumatic upper extremity amputation. BMC Musculoskelet Disord 25, 86 (2024). https://doi.org/10.1186/s12891-024-07183-w
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DOI: https://doi.org/10.1186/s12891-024-07183-w