Economic evaluation of treatment with orlistat in Italian obese patients

Authors: Iannazzo, S.1; Zaniolo, O.1; Pradelli, L.1

Source: Current Medical Research and Opinion, Volume 24, Number 1, January 2008 , pp. 63-74(12)

Publisher: LibraPharm

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Abstract:

The XENDOS study showed that behavioural and pharmacological therapy can decrease the risk of metabolic disorders in obese patients.

Methods: A probabilistic Bayesian Markov model simulating the outcomes of orlistat treatment on the obese Italian population has been developed with the WinBUGS software. The model integrates an algorithm to estimate cardiovascular risk based on Framingham Heart Study equations. Analyses adopted the societal cost perspective, including direct medical costs borne by both the National Health Service and the patient, since orlistat is not included in the Italian reimbursement list.

Results: The simulation on the Italian obese population estimated an average increase in quality-adjusted life expectancy, a reduction of cardiovascular events and new diabetes cases. The average incremental cost-utility ratio is €75.3 (7.6-180.6) × 1000/QALY. The subgroup analysis showed that the benefits are relatively greater in older patients and in patients with impaired glucose tolerance (IGT). Two hypotheses have been explored to estimate the impact of a potential reimbursement decision by the Italian NHS: (1) orlistat is given to every obese patient; (2) orlistat is given only to obese IGT patients with a previous glucose tolerance general screening program to assess their eligibility. The cost utility of the strategies are €42.3 (−22.16-108.7) and €10.16 (−60.4-38.76) × 1000/QALY, respectively.

Conclusion: Orlistat shows a good pharmacoeconomic profile and, in particular, the strategy of a screening programme to identify and treat the IGT subgroup has a cost-utility value of about €10000/QALY. This value is lower than that of several therapeutic strategies commonly accepted and reimbursed in developed countries.

Keywords: COST UTILITY; DIABETES; MARKOV MODEL; OBESITY; ORLISTAT; WINBUGS

Document Type: Research article

DOI: 10.1185/030079907X253591

Affiliations: 1: Advanced Research Srl, Turin, Italy

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