Abstract
The BODE index is the best recognized and validated prognostic index in COPD. However the exercise component (6 minute walk distance:6MWD) is not always feasible due to space. The 5-repetition sit-to-stand test (5STS) is a validated simple functional test of exercise performance that is feasible in most healthcare settings. We used the original BODE index cut-offs, replacing 6MWD with 5STS to develop the BODS index. We assessed the predictive performance of the BODS index for mortality
In a development cohort of 838 patients with stable COPD recruited from community-based clinics, we categorized patients according to BODS index (BODS 0-2, 3-4, 5-6 and 7-10). The primary outcome was time to death. We calculated hazard ratios (HR) using Cox proportional hazards regression, adjusting for age and sex.
During follow-up (mean (SD) duration 1451 (653) days), we documented 170 (20.3%) deaths. A Kaplan-Meier plot showed that time to death was reduced with worsening BODS index category (Logrank for trend p<0.001). BODS 5-6 and 7-10 categories (compared with BODS 0-2) were independently associated with increased all-cause mortality risk on multivariable analysis (HR 1.90 (95%CI 1.12 to 3.24);p=0.02 and 3.29 (95%CI 1.98 to 5.47);p<0.0001 respectively).
We propose that the BODS index, the components of which are all feasible in the community or home assessment of patients with COPD, provides additional prognostic information in COPD.
Footnotes
Cite this article as: European Respiratory Journal 2018 52: Suppl. 62, PA832.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2018