SEARCH:   Advanced

Blood, 15 February 2006, Vol. 107, No. 4, pp. 1712-1716. Prepublished online as a Blood First Edition Paper on October 20, 2005; DOI 10.1182/blood-2005-07-2661. This Article Full Text Full Text (PDF) All Versions of this Article: 2005-07-2661v1 107/4/1712    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Khoury, H. J. Articles by Horowitz, M. M. Search for Related Content PubMed PubMed Citation Articles by Khoury, H. J. Articles by Horowitz, M. M. Related Collections Transplantation Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  TRANSPLANTATION Impact of posttransplantation G-CSF on outcomes of allogeneic hematopoietic stem cell transplantation Hanna J. Khoury, Fausto R. Loberiza, Jr, Olle Ringdén, A. John Barrett, Brian J. Bolwell, Jean-Yves Cahn, Richard E. Champlin, Robert Peter Gale, Gregory A. Hale, Alvaro Urbano-Ispizua, Rodrigo Martino, Philip L. McCarthy, Pierre Tiberghien, Leo F. Verdonck, and Mary M. Horowitz From the Center for International Blood and Marrow Transplant Research (CIBMTR), Health Policy Institute, Medical College of Wisconsin, Milwaukee; Emory University School of Medicine, Atlanta, GA; the University of Nebraska Medical Center, Omaha; Huddinge University Hospital, Huddinge, Sweden; the National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD; the Cleveland Clinic Foundation, Cleveland, OH; Hôpital Jean Minjoz, Besançon, France; the M. D. Anderson Cancer Center, Houston, TX; the Center for Advanced Studies in Leukemia, Los Angeles, CA; St Jude Children's Research Hospital, Memphis, TN; the Postgraduate School of Hematology, Barcelona, Spain; Hospital Sant Creu I Sant Pau, Barcelona, Spain; the Roswell Park Cancer Institute, Buffalo, NY; Etablissement Français du Sang, Besançon, France; and University Hospital Utrecht, the Netherlands. Granulocyte colony-stimulating factor (G-CSF) is often administered after hematopoietic-cell transplantation (HCT) to accelerate neutrophil recovery, but it is unclear what impact G-CSF has on long-term transplantation outcomes. We analyzed within the database of the Center for International Blood and Marrow Transplant Research the impact of giving posttransplantation G-CSF on the outcomes of allogeneic HCT for acute myelogenous leukemia and chronic myelogenous leukemia in 2719 patients who underwent transplantation between 1995 and 2000. These included 1435 recipients of HLA-identical sibling bone marrow (BM), 609 recipients of HLA-identical peripheral-blood stem cells (PBSCs), and 675 recipients of unrelated donor BM transplants. Outcomes were compared between patients receiving or not receiving G-CSF within 7 days of HCT according to graft type. Median follow-up was more than 30 months (range, 2-87 months). G-CSF shortened the posttransplantation neutropenic period, but did not affect days +30 and +100 treatment-related mortality (TRM). Probabilities of acute and chronic graft-versus-host disease (GVHD), leukemia-free survival (LFS), and overall survival were similar whether or not G-CSF was given. Multivariate analyses confirmed that giving G-CSF did not affect the risk of GVHD, TRM, LFS, or survival. In conclusion, results of this study found no long-term benefit or disadvantage of giving G-CSF after transplantation to promote hematopoietic recovery. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. S. Miller and B. R. Blazar Response: The role of G-CSF on the risk of graft-versus-host disease after donor lymphocyte infusions Blood, May 15, 2008; 111(10): 5256 - 5257. [Full Text] [PDF] K. L. Andarawewa, A. C. Erickson, W. S. Chou, S. V. Costes, P. Gascard, J. D. Mott, M. J. Bissell, and M. H. Barcellos-Hoff Ionizing Radiation Predisposes Nonmalignant Human Mammary Epithelial Cells to Undergo Transforming Growth Factor {beta} Induced Epithelial to Mesenchymal Transition Cancer Res., September 15, 2007; 67(18): 8662 - 8670. [Abstract] [Full Text] [PDF]

	Copyright © 2006 by American Society of Hematology         Online ISSN: 1528-0020