SEARCH:   Advanced

Blood, 1 January 2004, Vol. 103, No. 1, pp. 133-135. Prepublished online as a Blood First Edition Paper on September 11, 2003; DOI 10.1182/blood-2003-06-2101. This Article Full Text Full Text (PDF) All Versions of this Article: 2003-06-2101v1 103/1/133    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Cogle, C. R. Articles by Scott, E. W. Search for Related Content PubMed PubMed Citation Articles by Cogle, C. R. Articles by Scott, E. W. Related Collections Hematopoiesis and Stem Cells Hemostasis, Thrombosis, and Vascular Biology Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  HEMATOPOIESIS Brief report Adult human hematopoietic cells provide functional hemangioblast activity Christopher R. Cogle, David A. Wainman, Marda L. Jorgensen, Steven M. Guthrie, Robert N. Mames, and Edward W. Scott From the Program in Stem Cell Biology and Regenerative Medicine, University of Florida Shands Cancer Center, Gainesville, FL. The murine adult hematopoietic stem cell is able to function as a hemangioblast, contributing both to blood reconstitution and to blood vessel repair in response to ischemic injury. We developed a novel mouse xenotransplantation model of retinal neovascularization to test human hematopoietic cell plasticity. Immunocompromised nonobese diabetic (NOD)/scid mice underwent myeloablative conditioning and transplantation with human CD34+ umbilical cord blood. After multilineage reconstitution was established, retinal ischemia was induced to promote neovascularization. Our results demonstrate human retinal neovascularization, thus revealing the functional hemangioblast activity of human hematopoietic cells. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: R. Ria, C. Piccoli, T. Cirulli, F. Falzetti, G. Mangialardi, D. Guidolin, A. Tabilio, N. Di Renzo, A. Guarini, D. Ribatti, et al. Endothelial Differentiation of Hematopoietic Stem and Progenitor Cells from Patients with Multiple Myeloma Clin. Cancer Res., March 15, 2008; 14(6): 1678 - 1685. [Abstract] [Full Text] [PDF] M. C. Yoder Hemangioblasts: of mice and men Blood, April 1, 2007; 109(7): 2667 - 2668. [Full Text] [PDF] G. C. Schatteman, M. Dunnwald, and C. Jiao Biology of bone marrow-derived endothelial cell precursors Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H1 - H18. [Abstract] [Full Text] [PDF] J. R. Harris, G. A. J. Brown, M. Jorgensen, S. Kaushal, E. A. Ellis, M. B. Grant, and E. W. Scott Bone Marrow-Derived Cells Home to and Regenerate Retinal Pigment Epithelium after Injury Invest. Ophthalmol. Vis. Sci., May 1, 2006; 47(5): 2108 - 2113. [Abstract] [Full Text] [PDF] J. P. Chute, G. G. Muramoto, H. K. Dressman, G. Wolfe, N. J. Chao, and S. Lin Molecular Profile and Partial Functional Analysis of Novel Endothelial Cell-Derived Growth Factors that Regulate Hematopoiesis Stem Cells, May 1, 2006; 24(5): 1315 - 1327. [Abstract] [Full Text] [PDF] B. Dekel, E. Shezen, S. Even-Tov-Friedman, H. Katchman, R. Margalit, A. Nagler, and Y. Reisner Transplantation of Human Hematopoietic Stem Cells into Ischemic and Growing Kidneys Suggests a Role in Vasculogenesis but Not Tubulogenesis Stem Cells, May 1, 2006; 24(5): 1185 - 1193. [Abstract] [Full Text] [PDF] E. J. Suuronen, S. Wong, V. Kapila, G. Waghray, S. C. Whitman, T. G. Mesana, and M. Ruel Generation of CD133+ cells from CD133- peripheral blood mononuclear cells and their properties Cardiovasc Res, April 1, 2006; 70(1): 126 - 135. [Abstract] [Full Text] [PDF] S. M. Guthrie, L. M. Curtis, R. N. Mames, G. G. Simon, M. B. Grant, and E. W. Scott The nitric oxide pathway modulates hemangioblast activity of adult hematopoietic stem cells Blood, March 1, 2005; 105(5): 1916 - 1922. [Abstract] [Full Text] [PDF] J. R. Gothert, S. E. Gustin, J. A. M. van Eekelen, U. Schmidt, M. A. Hall, S. M. Jane, A. R. Green, B. Gottgens, D. J. Izon, and C. G. Begley Genetically tagging endothelial cells in vivo: bone marrow-derived cells do not contribute to tumor endothelium Blood, September 15, 2004; 104(6): 1769 - 1777. [Abstract] [Full Text] [PDF] R. Torensma and C. G. Figdor Differentiating Stem Cells Mask Their Origins Stem Cells, May 1, 2004; 22(3): 250 - 252. [Full Text] [PDF]

	Copyright © 2004 by American Society of Hematology         Online ISSN: 1528-0020