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 Prepublished online as a Blood First Edition Paper on October 10, 2002; DOI 10.1182/blood-2002-07-2122.

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Blood, 1 March 2003, Vol. 101, No. 5, pp. 2064-2066

TRANSPLANTATION
Brief report

High-dose immune suppression and autologous hematopoietic stem cell transplantation in refractory Crohn disease

Richard K. Burt, Ann Traynor, Yu Oyama, and Robert Craig

From the Division of Immunotherapy, Northwestern University Medical School, Chicago, IL.

Two patients with severe Crohn disease, defined by a Crohn Disease Activity Index (CDAI) higher than 250 despite anti-tumor necrosis factor alpha  (TNF-alpha ), were treated by intense immune suppression and autologous hematopoietic stem cell transplantation (HSCT). Stem cells were mobilized from the peripheral blood using cyclophosphamide (2.0 g/m2) and granulocyte colony-stimulating factor (G-CSF; 5 µg/kg/d), enriched ex vivo by CD34+ selection, and reinfused after immune conditioning with cyclophosphamide (200 mg/kg) and equine anti-thymocyte globulin (ATG; 90 mg/kg). Patients have remained in remission (CDAI < 100) for 1 year since HSCT. We conclude that further HSCT studies for severe Crohn disease appear warranted.

© 2003 by The American Society of Hematology.
 

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