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Immunohistochemical Investigation of Metastasis-Related Chemokines in Deep-Infiltrating Endometriosis and Compromised Pelvic Sentinel Lymph Nodes

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Abstract

Endometriosis is a prevalent benign disease, despite sharing several similarities with malignancies, such as the possibility of lymphatic spread. In malignancies, chemokines play a sovereign role in the process of metastasis. Metastasis-related chemokine axes have not yet been assessed in deep-infiltrating endometriosis (DIE), and this investigation was the aim of our study. The expression of these chemokines was investigated by immunohistochemistry in rectovaginal DIE lesions and in matched pelvic sentinel lymph nodes (PSLNs) of patients with endometriosis (n = 27), and their expression in the eutopic endometrium (EE) of endometriosis-free women (n = 20) was used as controls. Their staining pattern in rectovaginal DIE, in endometriotic lesions affecting the PSLN as well as in the EE of patients without endometriosis was characterized for the first time. Overall, these chemokines were highly expressed in DIE and endometriosis in PSLN. Chemokines might be involved in the spread of endometriosis and should be further investigated.

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Authors and Affiliations

  1. Clinic for Gynecology, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany

    G. M. Borrelli MD, PhD, C. Köhler MD, PhD, A. M. Kaufmann PhD, V. Chiantera MD & S. Mechsner MD, PhD

  2. Department of Obstetrics and Gynecology, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil

    G. M. Borrelli MD, PhD & M. S. Abrão MD, PhD

  3. Institute of Pathology, Charité Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany

    E. T. Taube MD & S. Darb-Esfahani MD, PhD

  4. Department of Gynecology, Asklepios Klinik Harburg, Hamburg, Germany

    C. Köhler MD, PhD

Authors
  1. G. M. Borrelli MD, PhD
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  2. M. S. Abrão MD, PhD
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  3. E. T. Taube MD
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  4. S. Darb-Esfahani MD, PhD
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  5. C. Köhler MD, PhD
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  6. A. M. Kaufmann PhD
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  7. V. Chiantera MD
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  8. S. Mechsner MD, PhD
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Corresponding author

Correspondence to G. M. Borrelli MD, PhD.

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Borrelli, G.M., Abrão, M.S., Taube, E.T. et al. Immunohistochemical Investigation of Metastasis-Related Chemokines in Deep-Infiltrating Endometriosis and Compromised Pelvic Sentinel Lymph Nodes. Reprod. Sci. 22, 1632–1642 (2015). https://doi.org/10.1177/1933719115592711

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  • DOI: https://doi.org/10.1177/1933719115592711

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