Skip to main content
SpringerLink
Log in

Reproductive Ability After Uterine Artery Embolization in a Sheep Model: Observation Over 2 Seasons

  • Articles
  • Published:
Reproductive Sciences Aims and scope Submit manuscript

Abstract

Objective

To investigate the mid-term effect of uterine artery embolization (UAE) on fertility after bilateral UAE with either tris-acryl gelatin microspheres (TAGM) or gelatin particles (GP).

Materials and methods

Fertility was compared in 6 ewes that underwent UAE with TAGM, 6 ewes that underwent UAE with GP, and 6 control ewes. All ewes were artificially inseminated or naturally bred for 2 consecutive breeding seasons after UAE. Pregnancies in each breeding season were investigated.

Results

Overall, 36 lambs, all normal in appearance, were delivered after 2 breeding seasons. All 18 ewes delivered lambs in at least the first or second breeding season, with 13 having lambs in both the first and second breeding seasons. In the first breeding season after UAE, all 12 ewes in the UAE group delivered lambs, while 5 (83.3%) of the 6 ewes in the control group did. In the second breeding season, 9 (90%) of the 10 ewes that were alive in the UAE group delivered lambs, while 5 (83.3%) of 6 ewes in the control group did. There were no significant differences in the rate of ewes delivering in the first and second breeding season between control and UAE groups (P =.3333; first season, P >.9999; second season, Fisher exact probability test).

Conclusion

The mid-term influence of UAE on reproductive ability in sheep was minimal.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Ravina JH, Herbreteau D, Ciraru-Vigneron N, et al. Arterial embolization to treat uterine myomata. Lancet. 1995; 346(8976):671–672.

    Article  CAS  Google Scholar 

  2. Mara M, Maskova J, Fucikova Z, Kuzel D, Belsan T, Sosna O. Midterm clinical and first reproductive results of a randomized controlled trial comparing uterine fibroid embolization and myomectomy. Cardiovasc Interv Radiol. 2008;31(1):73–85.

    Article  Google Scholar 

  3. Goldberg J, Pereira L, Berghella V. Pregnancy after uterine artery embolization. Obstet Gynecol. 2002;100(5 pt 1):869–872.

    PubMed  Google Scholar 

  4. Walker WJ, McDowell S. Pregnancy after uterine artery embolization for leiomyomata: a series of 56 completed pregnancies. Am J Obstet Gynecol. 2006;195(5):1266–1271.

    Article  Google Scholar 

  5. Pabon IP, Magret JP, Unzurrunzaga EA, Garcia IM, Catalan IB, Vieco L. Pregnancy after uterine fibroid embolization: follow-up of 100 patients using tris-acryl gelatin microspheres. Fertil Steril. 2008;90(6):2356–2360.

    Article  Google Scholar 

  6. Spies JB, Ascher SM, Roth AR, Kim J, Levy EB, Gomez-Jorge J. Uterine artery embolization for leiomyomata: midterm results. Obstet Gynecol. 2001;98(1):29–34.

    CAS  PubMed  Google Scholar 

  7. Pelage JP, Dref OL, Beregi JP, et al. Limited uterine artery embolization with tris-acryl gelatin microspheres for uterine fibroids. J Vasc Interv Radiol. 2003;14(1):15–20.

    Article  Google Scholar 

  8. Katsumori T, Nakajima K, Mihara T, Tokuhiro M. Uterine artery embolization using gelatin sponge particles alone for symptomatic uterine fibroids: midterm results. Am J Roentgenol. 2002;178(1):135–139.

    Article  Google Scholar 

  9. Myers E. Uterine artery embolization: what more do we need to know? Obstet Gynecol. 2002;100(5 pt 1):847–848.

    PubMed  Google Scholar 

  10. Laurent A, Pelage JP, Wassef M, Martal J. Fertility after bilateral uterine artery embolization in sheep model. Fertil Steril. 2009;89(5 suppl):1371–1383.

    Article  Google Scholar 

  11. Yamagami T, Yoshimatsu R, Matsumoto T, et al. Fertility after uterine artery embolization: investigation using a sheep model. Reprod Sci. 2010;17(4):350–357.

    Article  Google Scholar 

  12. Osuga K, Miyayama S, Yamagami T, Anai H, Takahashi M, Nakamura H. New porous gelatin particles for hepatic arterial embolization-investigation of passage through current microcatheters. Jpn J Cancer Chemother. 2007;34(1): 59–64.

    CAS  Google Scholar 

  13. Fukui Y, Iida K, Okada A, Zyouzyou Y, Wachi S, Togawa M. Fertility of estrus-induced ewes during the non-breeding season and artificially inseminated with frozen semen imported from New Zealand. J Reprod Dev. 2002;48(5): 485–488.

    Article  Google Scholar 

  14. Kohno H, Okamoto C, Iida K, et al. Comparison of estrus induction and subsequent fertility with two different intravaginal devices in ewes during the non-breeding season. J Reprod Dev. 2005;51(6):805–812.

    Article  CAS  Google Scholar 

  15. Fukui Y, Kohno H, Togari T, Hiwasa M. Fertility of ewes inseminated intrauterinally with frozen semen using extender containing bovine serum albumin. J Reprod Dev. 2007;53(4): 959–962.

    Article  Google Scholar 

  16. Mara M, Fucikova Z, Kuzel D, Masakova J, Dundr P, Zizka Z. Hysteroscopy after uterine fibroid embolization in women of fertile age. J Obstet Gynecol Res. 2007;33(3): 316–324.

    Article  Google Scholar 

  17. Hehenkamp WJ, Volkers NA, Broekmans FJ, et al. Loss of ovarian reserve after uterine artery embolization: a randomized comparison with hysterectomy. Hum Reprod. 2007; 22(7):1996–2005.

    Article  CAS  Google Scholar 

  18. Spies JB, Roth AR, Gonsalves SM, Murphy-Skrzyniarz K. Ovarian function after uterine artery embolization for leiomyomata: assessment with use of serum follicle stimulating hormone assay. J Vasc Interv Radiol. 2001;12(4): 437–442.

    Article  CAS  Google Scholar 

  19. Pelage JP, Laurent A, Bonneau M, Wassef M, Rymer R, Merland J. Arterial blood supply to the uterus in nonpregnant sheep: a pertinent model for clinical practice? Invest Radiol. 2001; 36(12):721–725.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii, Kawaramachi-Hirokoji, Kamigyo, 602-8566, Kyoto, Japan

    Takuji Yamagami MD, PhD, Rika Yoshimatsu MD, PhD, Tomohiro Matsumoto MD, PhD & Tsunehiko Nishimura MD, PhD

  2. Department of Radiology, Kyoto First Red Cross Hospital, Motomachi, Higashiyama, Kyoto, Japan

    Tomohiro Matsumoto MD, PhD

  3. Laboratory of Animal Reproduction, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido, Japan

    Hiroshi Anzai, Masahiro Yoshizawa & Yutaka Fukui PhD

  4. Boya Farm, Aza-Kiyomi, Ikeda-cho, Hokkaido, Japan

    Hiroshi Anzai

Authors
  1. Takuji Yamagami MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Rika Yoshimatsu MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Tomohiro Matsumoto MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Hiroshi Anzai
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Masahiro Yoshizawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Yutaka Fukui PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Tsunehiko Nishimura MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Takuji Yamagami MD, PhD.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yamagami, T., Yoshimatsu, R., Matsumoto, T. et al. Reproductive Ability After Uterine Artery Embolization in a Sheep Model: Observation Over 2 Seasons. Reprod. Sci. 17, 679–684 (2010). https://doi.org/10.1177/1933719110369010

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1177/1933719110369010

Keywords

Search

Navigation