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A Tumor Necrosis Factor—α Promoter Polymorphism and Pregnancy Complications: Results of a Prospective Cohort Study in 1652 Pregnant Women

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Abstract

The purpose of this article is to investigate the frequency of the tumor necrosis factor— α (TNF- α) -308 G/A single nucleotide polymorphism in women with intrauterine fetal death, preeclampsia, preterm delivery, and small-for-gestational-age (SGA) infants. In a prospective cohort study, DNA from 1652 consecutive pregnant women was analyzed for TNF- α -308 G/A by polymerase chain reaction. Women who developed at least 1 of the predefined pregnancy complications were used as cases and compared to women without pregnancy complications. Of 1652 women, 268 (16.2%) developed at least 1 pregnancy complication. TNF- α -308 G/A allele frequencies (G: 463/536 [86%] and A: 73/536 [14%] vs G: 2366/2768 [85%] and A: 402/2768 [15%], respectively; P =.6; odds ratio [OR], 0.93; 95% confidence interval [CI], 0.69–1.25) and genotype distributions (G/G + G/A: 259/268 [97%] and A/A 9/268 [3%] vs G/G + G/A: 1352/1384 [98%] and A/A 32/1384 [2%], respectively; P =.4; OR, 0.20; 95% CI, 0.002–14.81) were not significantly different between cases and controls. The authors observed no statistically significant difference in TNF-a -308 G/A genotype distributions comparing controls and women with intrauterine fetal death, preeclampsia, preterm delivery < 34 weeks’ gestation, preterm delivery > 34 weeks’ gestation, SGA infants < 3rd percentile, and SGA infants of the 4th to 10th percentile. TNF- α -308 G/A is not a genetic marker for identifying women at increased risk of common pregnancy complications.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Ludwig Boltzmann Institute of Clinical Obstetrics and Gynecology, Danube Hospital/SMZ-Ost, Vienna, Austria

    Felix Stonek MD, Erich Hafner MD, Martin Metzenbauer MD & Karl Philipp MD

  2. Department of Obstetrics and Gynecology, Medical University of Vienna, Waehringer Guertel 18-20, A-1090, Vienna, Austria

    Eva-Katrin Bentz MD, Lukas A. Hefler MD & Clemens B. Tempfer MD

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  1. Felix Stonek MD
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  2. Eva-Katrin Bentz MD
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  3. Erich Hafner MD
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  4. Martin Metzenbauer MD
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  5. Karl Philipp MD
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  6. Lukas A. Hefler MD
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  7. Clemens B. Tempfer MD
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Correspondence to Clemens B. Tempfer MD.

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Stonek, F., Bentz, EK., Hafner, E. et al. A Tumor Necrosis Factor—α Promoter Polymorphism and Pregnancy Complications: Results of a Prospective Cohort Study in 1652 Pregnant Women. Reprod. Sci. 14, 425–429 (2007). https://doi.org/10.1177/1933719107305213

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  • DOI: https://doi.org/10.1177/1933719107305213

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