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Autism, Vol. 12, No. 3, 293-307 (2008)
DOI: 10.1177/1362361307089518
© 2008 The National Autistic Society, SAGE Publications

Acetaminophen (paracetamol) use, measles-mumps-rubella vaccination, and autistic disorder

The results of a parent survey

Stephen T. Schultz

University of California San Diego, and San Diego State University, USA, Stephen.schultz{at}med.navy.mil, stevendri{at}hotmail.com

Hillary S. Klonoff-Cohen

University of California San Diego, USA

Deborah L. Wingard

University of California San Diego, USA

Natacha A. Akshoomoff

University of California San Diego, USA

Caroline A. Macera

San Diego State University, USA

Ming Ji

San Diego State University, USA

The present study was performed to determine whether acetaminophen (paracetamol) use after the measles-mumps-rubella vaccination could be associated with autistic disorder. This case-control study used the results of an online parental survey conducted from 16 July 2005 to 30 January 2006, consisting of 83 children with autistic disorder and 80 control children. Acetaminophen use after measles-mumps-rubella vaccination was significantly associated with autistic disorder when considering children 5 years of age or less (OR 6.11, 95% CI 1.42—26.3), after limiting cases to children with regression in development (OR 3.97, 95% CI 1.11—14.3), and when considering only children who had post-vaccination sequelae (OR 8.23, 95% CI 1.56—43.3), adjusting for age, gender, mother's ethnicity, and the presence of illness concurrent with measles-mumps-rubella vaccination. Ibuprofen use after measles-mumps-rubella vaccination was not associated with autistic disorder. This preliminary study found that acetaminophen use after measles-mumps-rubella vaccination was associated with autistic disorder.

Key Words: acetaminophen • autism • paracetamol • vaccination


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