International Journal of Surgical Pathology

 

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International Journal of Surgical Pathology, Vol. 15, No. 4, 401-407 (2007)
DOI: 10.1177/1066896907302370

Reviews

Primary Malignant Melanoma of the Transverse Colon: Report of a Case and Review of the Literature

Barton Kenney, MD

Department of Pathology, Yale University School of Medicine, barton.kenney{at}yale.edu

Jorge Dotto, MD

Department of Pathology, Yale University School of Medicine

Robert Homer, MD, PhD

Department of Pathology, Yale University School of Medicine

Nelofar Shafi, MD

Department of Pathology, Veterans Affairs Connecticut Healthcare System, West Haven Connecticut

Larisa Davydova, MD

Department of Pathology, Veterans Affairs Connecticut Healthcare System, West Haven Connecticut

Gastrointestinal involvement by malignant melanoma is predominantly a metastatic phenomenon. Although primary malignant melanoma of the gastrointestinal tract has been documented in the esophagus, stomach, small bowel, and anorectum, the incidence of primary melanoma of the colon is rare and remains controversial in most cases. We present a case of solitary malignant melanoma of the transverse colon occurring in a 64-year-old African American male patient. Complete dermatologic and ophthalmologic examinations revealed no evidence of a cutaneous or an ocular primary lesion. Microscopic examination of the resection specimen revealed malignant melanoma, which was confirmed by immunohistochemical positivity for S100 and melan-A. We believe that this tumor represents a primary colonic malignant melanoma.

Key Words: melanoma • c-kit • CD117 • S100 • HMB45 • melan-A • gastrointestinal • bowel • transverse colon


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