Abstract: Objective To explore the safety and feasibility of transumblical single-port laparoendoscopy in hysteromyomectomy. Methods Clinical data of 60 patients, who underwent laparoendoscopic myomectony by the same operator in Dalian Maternal and Child Care Service Hospital from January to December 2017, were collected. The patients were divided into two groups: 30 patients with single-port laparoendoscopy (single-port group) and 30 patients with multi-ports laparoendoscopy (multi-ports group). The indicators of both groups were analyzed and compared, including operation time, intraoperative bleeding, hemoglobin change, postoperative hospitalization, postoperative morbidity, postoperative complications, postoperative pain score, body image scale and cosmetic score, etc. Results All procedures were performed successfully in both groups without conversion to open surgery. No significant differences（P＞0.05）werr observed in intraoperative blood loss ［(44.00±8.21）vs.（40.00±6.32）mL］, hemoglobin change ［(11.13±3.89）vs.（9.33±2.41）g/L］, postoperative hospitalization ［(4.40±0.74）vs.（4.87±0.64）d］, and postoperative morbidity between the single-port group and the multi-ports group. The operation time was ［(89.00±14.04）vs.（55.23±15.47）min］, postoperative pain score ［(5.03±0.39）vs.（5.90±0.61）］, body image scale ［(5.07±0.26）vs.（5.87±0.74）］, cosmetic score ［(40.27±1.28）vs.（36.47±2.07）］, these clinical parameters were statistical different (all P<0.05). None of the groups showed postoperative morbidity. No patient had postoperative complications except one’s incision was healed late. Conclusions Transumblical single-port laparoendoscopic myomectomy is feasible and has the same safety and therapeutic effectiveness as the conventional laparoendoscopy. The postprocedural appearance is more beautiful than multi-ports laparoendoscopy and caters to the beauty needs of women.