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潘秀华, 吴正红, 祁小乐. CRISPR/Cas9递送系统的研究现状及应用进展[J]. 中国药科大学学报, 2020, 51(1): 10-18. DOI: 10.11665/j.issn.1000-5048.20200102
引用本文: 潘秀华, 吴正红, 祁小乐. CRISPR/Cas9递送系统的研究现状及应用进展[J]. 中国药科大学学报, 2020, 51(1): 10-18. DOI: 10.11665/j.issn.1000-5048.20200102
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PAN Xiuhua, WU Zhenghong, QI Xiaole. Research status and application progress of CRISPR/Cas9 delivery system[J]. Journal of China Pharmaceutical University, 2020, 51(1): 10-18. DOI: 10.11665/j.issn.1000-5048.20200102
Citation: PAN Xiuhua, WU Zhenghong, QI Xiaole. Research status and application progress of CRISPR/Cas9 delivery system[J]. Journal of China Pharmaceutical University, 2020, 51(1): 10-18. DOI: 10.11665/j.issn.1000-5048.20200102
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CRISPR/Cas9递送系统的研究现状及应用进展

Research status and application progress of CRISPR/Cas9 delivery system

    摘要
  • 摘要: 针对CRISPR/Cas9系统在DNA、RNA和蛋白3种水平的递送形式，本文着重介绍了CRISPR/Cas9系统的病毒载体和非病毒载体的研究现状和CRISPR/Cas9系统递送的新策略，及其在生物医学领域和基因相关疾病治疗的应用进展。通过对CRISPR/Cas9系统递送和基因治疗策略进行总结与阐述，为创新药物的发现和基因治疗的开发提供新思路。

     

    Abstract: Based on the three delivery forms of CRISPR/Cas9 system at the levels of DNA, RNA and protein, this paper mainly approaches the development and new strategies of CRISPR/Cas9 delivery systems, as well as their application in the biomedical field and the clinical treatment of gene-related diseases. By summarizing and elaborating the CRISPR/Cas9 system delivery and gene therapy strategy, new ideas are provided for the discovery of innovative drugs and the development of gene therapy.

     

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