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Home / Journal of Nanoscience and Nanotechnology, Volume 18, Number 6

Silver Nanoparticles Modified with Sodium Triphosphate: Antibacterial Activity, Hemocompatibility and Cytotoxicity

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In this study, we report silver nanoparticles (Ag NPs) modified with sodium triphosphate (STTP) (Ag–STPP NPs) prepared by a simple surface modification and chemical reduction method. It was confirmed by 31P NMR spectroscopy that STPP was successfully introduced to the surface of Ag NPs. It was revealed by conductivity change measurements, bacterial growth kinetics and antibacterial efficiency tests that Ag–STPP NPs still retained the strong antibacterial ability. It was demonstrated by hemolysis assays, red blood cell morphology measurements, plasma recalcification time and in vitro clotting times that Ag–STPP NPs had improved hemocompatibility. It was also implied by cell viability measurements that Ag–STPP NPs possessed low cytotoxicity and high cytocompatibility. These findings, combined with the low-cost and ease of synthesis, make Ag–STPP NPs a promising candidate for biomedical applications.

Keywords: Antibacterial Activity; Cytotoxicity; Hemocompatibility; Silver Nanoparticles; Sodium Triphosphate

Document Type: Research Article

Affiliations: 1: Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of 3D Printing Equipment and Manufacturing, National and Local Joint Engineering Research Center of Biomedical Functional Materials, Jiangsu Engineering Research Center for Biomedical Function Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210097, China 2: Medical School, Nanjing University, Nanjing 210093, China 3: School of Material Engineering, Nanjing Institute of Technology, Nanjing 211167, Jiangsu, China

Publication date: 01 June 2018

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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