Novel Fabrication of Full Parylene-Isolated Neuroprobes
A novel 8-channel neuroprobe completely protected by biocompatible parylene C was fabricated in this study. Instead of conventional etching, laser micromachining was utilized to define the sharp tip. Sacrificial aluminum wires were bound on the platinum electrodes, and then the neuroprobes were fully insulated by parylene. Finally the aluminum wires were broken by shear force and etched chemically to expose the electrodes. The shank of the neuroprobe is 7-mm long with a 0.5×0.5 mm2 cross-section area. We have used the neuroprobe to record the neuronal responses of rat's primary somatosensory cortex. Based on the consideration that parylene has good biocompatibility and thus less tissue damage, we believed that this probe could serve the purpose of long-term recording.
Keywords: BIOCOMPATIBLE; MICROELECTROMECHANICAL SYSTEM (MEMS); NEUROPROBE; PARYLENE
Document Type: Short Communication
Publication date: 01 June 2009
- Bionanoscience attempts to harness various functions of biological macromolecules and integrate them with engineering for technological applications. It is based on a bottom-up approach and encompasses structural biology, biomacromolecular engineering, material science, and engineering, extending the horizon of material science. The journal aims at publication of (i) Letters (ii) Reviews (3) Concepts (4) Rapid communications (5) Research papers (6) Book reviews (7) Conference announcements in the interface between chemistry, physics, biology, material science, and technology. The use of biological macromolecules as sensors, biomaterials, information storage devices, biomolecular arrays, molecular machines is significantly increasing. The traditional disciplines of chemistry, physics, and biology are overlapping and coalescing with nanoscale science and technology. Currently research in this area is scattered in different journals and this journal seeks to bring them under a single umbrella to ensure highest quality peer-reviewed research for rapid dissemination in areas that are in the forefront of science and technology which is witnessing phenomenal and accelerated growth.
- Editorial Board
- Information for Authors
- Subscribe to this Title
- Ingenta Connect is not responsible for the content or availability of external websites
- Access Key
- Free content
- Partial Free content
- New content
- Open access content
- Partial Open access content
- Subscribed content
- Partial Subscribed content
- Free trial content