This Article Full Text Full Text (PDF) All Versions of this Article: 50/4/708    most recent HYPERTENSIONAHA.107.095257v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ellington, A. A. Articles by Kullo, I. J. Search for Related Content PubMed PubMed Citation Articles by Ellington, A. A. Articles by Kullo, I. J. Related Collections Cardio-renal physiology/pathophysiology Other hypertension

(Hypertension. 2007;50:708.)
© 2007 American Heart Association, Inc.

XVIIth Scientific Meeting of the Inter-American Society of Hypertension

Association of Plasma Resistin With Glomerular Filtration Rate and Albuminuria in Hypertensive Adults

Allison A. Ellington; A. Rauoof Malik; George G. Klee; Stephen T. Turner; Andrew D. Rule; Thomas H. Mosley, Jr; Iftikhar J. Kullo

From the Division of Cardiovascular Diseases (A.A.E., A.R.M., I.J.K.), Department of Laboratory Medicine and Pathology (G.G.K.), Division of Nephrology and Hypertension (S.T.T., A.D.R.), Mayo Clinic, Rochester, Minn; and the Department of Medicine (Geriatrics), University of Mississippi Medical Center (T.H.M.), Jackson.

Correspondence to Iftikhar J. Kullo, Division of Cardiovascular Diseases, Mayo Clinic, 200 First St Southwest, Rochester, MN 55905. E-mail kullo.iftikhar{at}mayo.edu

Resistin, a recently discovered proinflammatory cytokine, has been variably associated with insulin resistance, inflammation, and renal dysfunction. We investigated the association of plasma resistin with estimated glomerular filtration rate and albuminuria in 1575 hypertensive adults without known coronary heart disease or stroke (857 blacks and 718 non-Hispanic whites). Resistin was measured by a solid phase sandwich immunoassay, estimated glomerular filtration rate was estimated from serum creatinine, and albuminuria was expressed as urine albumin:creatinine ratio. After adjustment for coronary heart disease risk factors (age, sex, body mass index, smoking history, systolic blood pressure, diabetes, and total and high-density lipoprotein cholesterol) and use of renin-angiotensin blockers and statins, higher plasma resistin levels were associated with lower estimated glomerular filtration rate in both ethnic groups (each P<0.0001); the association remained significant after further adjustment for a marker of insulin resistance (homeostasis model assessment for insulin resistance) and a marker of inflammation (plasma C-reactive protein) and was seen in subjects with and without diabetes (each P<0.0001) in both ethnic groups. Higher plasma resistin levels were associated with a higher urine albumin:creatinine ratio in black subjects with diabetes (P<0.0001) and non-Hispanic white subjects with diabetes (P=0.032), independent of coronary heart disease risk factors, hypertension medication use, and statin use; the association remained significant after additional adjustment for homeostasis model assessment for insulin resistance and C-reactive protein. In adults with hypertension, higher circulating resistin levels were associated with a lower estimated glomerular filtration rate and with increased urine albumin:creatinine ratio in the presence of concomitant diabetes. This association was independent of coronary heart disease risk factors and markers of insulin resistance and inflammation.

Key Words: glomerular filtration rate • albuminuria • resistin • insulin resistance • inflammation

This article has been cited by other articles:

				Y. Tabara, M. Igase, H. Osawa, H. Makino, T. Miki, and K. Kohara Resistin, Glomerular Filtration Rate, and Insulin Resistance Hypertension, February 1, 2008; 51(2): e11 - e11. [Full Text] [PDF]

				A. A. Ellington, A. R. Malik, G. G. Klee, and I. J. Kullo Response to Resistin, Glomerular Filtration Rate, and Insulin Resistance Hypertension, February 1, 2008; 51(2): e12 - e12. [Full Text] [PDF]

				Y. Takata, H. Osawa, M. Kurata, M. Kurokawa, J. Yamauchi, M. Ochi, W. Nishida, T. Okura, J. Higaki, and H. Makino Hyperresistinemia Is Associated With Coexistence of Hypertension and Type 2 Diabetes Hypertension, February 1, 2008; 51(2): 534 - 539. [Abstract] [Full Text] [PDF]