This Article Full Text Full Text (PDF) All Versions of this Article: 27/12/2650    most recent ATVBAHA.107.153288v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hamburg, N. M. Articles by Vita, J. A. Search for Related Content PubMed PubMed Citation Articles by Hamburg, N. M. Articles by Vita, J. A. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB CHOLESTEROL Medline Plus Health Information High Blood Pressure

(Arteriosclerosis, Thrombosis, and Vascular Biology. 2007;27:2650.)
© 2007 American Heart Association, Inc.

Vascular Biology

Physical Inactivity Rapidly Induces Insulin Resistance and Microvascular Dysfunction in Healthy Volunteers

Naomi M. Hamburg; Craig J. McMackin; Alex L. Huang; Sherene M. Shenouda; Michael E. Widlansky; Eberhard Schulz; Noyan Gokce; Neil B. Ruderman; John F. Keaney, Jr; Joseph A. Vita

From the Evans Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Mass.

Correspondence to Joseph A. Vita, MD, Section of Cardiology, Boston Medical Center, 88 East Newton Street, Boston, MA 02118. E-mail jvita{at}bu.ed

Objectives— Sedentary lifestyle increases the risk of cardiovascular disease and diabetes. Vascular dysfunction contributes to atherogenesis and has been linked to insulin resistance.

Methods and Results— We measured insulin sensitivity by glucose tolerance test and vascular function by ultrasound and venous occlusion plethysmography in 20 healthy subjects (14 men, 6 women) at baseline and during 5 days of bed rest. Bed rest led to a 67% increase in the insulin response to glucose loading (P<0.001) suggesting increased insulin resistance and produced increases in total cholesterol and triglycerides. Bed rest led to decreased reactive hyperemia in the forearm (1317±404 to 1112±260 mL/min, P=0.01) and the calf (28.5±7.0 to 22.2±8.7 mL/min/dL, P=0.003) indicating impaired microvascular function. Bed rest decreased brachial artery diameter and increased systolic blood pressure suggesting increased basal arterial tone. There were no changes in circulating inflammatory markers arguing against systemic inflammation as a mechanism for vascular dysfunction in this setting.

Conclusions— Physical inactivity was associated with the development of insulin resistance, dyslipidemia, increased blood pressure, and impaired microvascular function in healthy volunteers. Our findings may provide insight into the pathogenesis of vascular disease in sedentary individuals and emphasize that even short-term physical inactivity may have adverse metabolic and vascular consequences.

Physical inactivity is associated with cardiovascular disease. We examined the effect of 5 days of bed rest on insulin resistance and vascular function in healthy subjects. Bed rest induced vascular dysfunction, insulin resistance, dyslipidemia, and increased blood pressure. Our findings provide insight into the pathogenesis of vascular disease in sedentary individuals.

Key Words: insulin resistance • sedentary lifestyle • obesity • endothelium • blood pressure • reactive hyperemia

This article has been cited by other articles:

				D. M. Needham Mobilizing Patients in the Intensive Care Unit: Improving Neuromuscular Weakness and Physical Function JAMA, October 8, 2008; 300(14): 1685 - 1690. [Abstract] [Full Text] [PDF]