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(Stroke. 2005;36:673.)
© 2005 American Heart Association, Inc.

Research Report

Soluble CD40L and Cardiovascular Risk in Asymptomatic Low-Grade Carotid Stenosis

Salvatore Novo, MD; Stefania Basili, MD; Rosalba Tantillo, MD; Angela Falco, MD; Valentina Davì, MD; Giuseppina Novo, MD; Egle Corrado, MD Giovanni Davì, MD

From the Department of Clinical Medicine and Emerging Pathologies (S.N., R.T., V.D., G.N., C.E.), University of Palermo, Italy; the Department of Medical Therapy (S.B.), University of Rome "La Sapienza," Italy; and the Center of Excellence on Aging (A.F., G.D.), "G. d’Annunzio" University Foundation, University of Chieti, Italy.

Correspondence to Dr Giovanni Davì, "G. d’Annunzio" University Foundation, University of Chieti School of Medicine, Via Colle dell’Ara, 66013 Chieti, Italy. E-mail gdavi{at}unich.it

Background and Purpose— We investigated whether soluble CD40L (sCD40L) may predict the risk of cardiovascular (CV) events in patients with asymptomatic carotid plaques.

Methods— Forty-two patients with asymptomatic low-grade carotid stenosis (ALCS) and 21 controls without any carotid stenosis were enrolled. All subjects had at least a major cardiovascular risk factor (CRF). Plasma levels of C-reactive protein (CRP), IL-6, and sCD40L were measured. Subjects were reviewed every 12 months (median follow-up, 8 years).

Results— ALCS patients had higher (P<0.0001) CRP, IL-6, and sCD40L than controls. Fourteen patients experienced a CV event. Cox regression analysis showed that only high sCD40L levels (P=0.003) independently predicted cardiovascular risk.

Conclusions— High levels of sCD40L may predict the risk of CV events in ALCS.

Key Words: atherosclerosis • carotid stenosis • inflammation • risk factors

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