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(Hypertension. 2006;48:711.)
© 2006 American Heart Association, Inc.

Original Articles

Hypertension Produced by Reductions in Uterine Perfusion in the Pregnant Rat

Role of Interleukin 6

Giovani Gadonski; B. Babbette D. LaMarca; Elizabeth Sullivan; William Bennett; Derrick Chandler; Joey P. Granger

From the Departments of Physiology and Obstetrics–Gynecology and Center for Excellence in Cardiovascular–Renal Research, University of Mississippi Medical Center, Jackson, Miss.

Correspondence to Joey P. Granger, University of Mississippi Medical Center, Department of Physiology and Biophysics, 2500 North State St, Jackson, MS 39216-4505. E-mail jgranger{at}physiology.umsmed.edu

The purpose of this study was to determine the role of interleukin (IL) 6 in mediating the increase in arterial pressure (AP) in response to chronic reductions in uterine perfusion pressure (RUPP) in pregnant rats. AP was higher in RUPP rats (138±1 mm Hg) than in normal pregnant (NP) rats (104±1 mm Hg). Serum IL-6 levels in the RUPP rats were 104.5±28.6 pg/mL as compared with 36.6±7.4 pg/mL in NP rats. To determine the long-term effects of a 2- to 3-fold elevation in plasma IL-6 on renal function and AP in pregnant rats, we infused IL-6 for 5 days (2.5 ng/day) in NP rats starting at day 14 of gestation. Five days later, serum IL-6 levels were 55.5±6.5 pg/mL in the control NP rats and 157.0±36.1 pg/mL in the IL-6–treated NP rats. AP was higher in the IL-6–treated NP rats (115±3 mm Hg) as compared with NP controls (101±1 mm Hg) at day 19 of gestation. Renal plasma flow and GFR were lower in the IL-6–treated NP rats than in the NP group. IL-6 increased plasma renin activity but did not affect endothelin in IL-6–treated NP rats. In contrast to the NP rats, IL-6 had no effect on AP or renal hemodynamics in virgin rats. In summary, these data indicate that plasma IL-6 is elevated in response to chronic reductions in uterine perfusion in pregnant rats and that a comparable elevation in plasma IL-6 increases AP and reduces renal function in pregnant rats.

Key Words: kidney • cytokines • hypertension • endothelin

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