Thromb Haemost 2014; 111(06): 1187-1190
DOI: 10.1160/TH13-08-0642
Letters to the Editor
Schattauer GmbH

Unravelling the Smokers’ Paradox: Cigarette smoking, high-risk coronary artery disease and enhanced clinical efficacy of oral P2Y12 inhibitors

Paul A. Gurbel
1   Sinai Center for Thrombosis Research, Baltimore, Maryland, USA
,
Brian A. Baker
2   Daiichi Sankyo, Inc., Parsippany, New Jersey, USA
,
William L. Bailey
2   Daiichi Sankyo, Inc., Parsippany, New Jersey, USA
,
Kevin P. Bliden
1   Sinai Center for Thrombosis Research, Baltimore, Maryland, USA
,
Udaya S. Tantry
1   Sinai Center for Thrombosis Research, Baltimore, Maryland, USA
› Author Affiliations
Further Information

Publication History

Received: 05 August 2013

Accepted after major revision: 05 January 2014

Publication Date:
02 December 2017 (online)

 

 
  • References

  • 1 Åberg A, Bergstrand R, Johansson S. et al. Cessation of smoking after myocardial infarction: effects on mortality after 10 years. Br Heart J 1983; 49: 416-422.
  • 2 Centers for Disease Control and Prevention (US); National Center for Chronic Disease Prevention and Health Promotion (US); Office on Smoking and Health (US). How Tobacco Smoke Causes Disease: The Biology and Behavioral Basis for Smoking-Attributable Disease: A Report of the Surgeon General. Atlanta (GA): Centers for Disease Control and Prevention (US); 2010: 6 Cardiovascular Diseases. Available from: http://www.ncbi.nlm.nih.gov/books/NBK53012/ Accessed June 11, 2013
  • 3 Csordas A, Bernhard D. The biology behind the atherothrombotic effects of cigarette smoke. Nat Rev Cardiol 2013; 10: 219-230.
  • 4 Barua RS, Ambrose JA. Mechanisms of coronary thrombosis in cigarette smoke exposure. Arterioscler Thromb Vasc Biol 2013; 33: 1460-1467.
  • 5 Newby DE, Wright RA, Labinjoh C. et al. Endothelial dysfunction, impaired endogenous fibrinolysis, and cigarette smoking:a mechanism for arterial thrombosis and myocardial infarction. Circulation 1999; 99: 1411-1415.
  • 6 Kelly TL, Gilpin E, Ahnve S. et al. Smoking status at the time of acute myocardial infarction and subsequent prognosis. Am Heart J 1985; 110: 535-541.
  • 7 Sparrow D, Dawber TR. The influence of cigarette smoking on prognosis after a first myocardial infarction. A report from the Framingham study. J Chronic Dis 1978; 31: 425-432.
  • 8 Gomez MA, Karagounis LA, Allen A. et al. Effect of cigarette smoking on coronary patency after thrombolytic therapy for myocardial infarction. TEAM-2 investigators. Second multicenter thrombolytic trials of eminase in acute myocardial infarction. Am J Cardiol 1993; 72: 373-378.
  • 9 Barbash GI, Reiner J, White HD. et al. Evaluation of paradoxic beneficial effects of smoking in patients receiving thrombolytic therapy for acute myocardial infarction: mechanism of the “smoker’s paradox” from the GUSTO-I trial, with angiographic insights. Global utilization of streptokinase and tissue-plasminogen activator for occluded coronary arteries. J Am Coll Cardiol 1995; 26: 1222-1229.
  • 10 Addad F, Dridi Z, Jemmali M. et al. “Smoker’s paradox” and reperfusion’s strategy in acute myocardial infarction. Ann Cardiol Angiol 2010; 59: 183-189.
  • 11 Lee KL, Woodlief LH, Topol EJ. et al. Predictors of 30-day mortality in the era of reperfusion for acute myocardial infarction. Results from an international trial of 41,021 patients. GUSTO-I investigators. Circulation 1995; 91: 1659-1668.
  • 12 Andrikopoulos GK, Richter DJ, Dilaveris PE. et al. In-hospital mortality of habitual cigarette smokers after acute myocardial infarction; the “smoker’s paradox” in a countrywide study. Eur Heart J 2001; 22: 776-784.
  • 13 Aune E, Roislien J, Mathisen M. et al. The “smoker’s paradox” in patients with acute coronary syndrome: a systematic review. BMC Med 2011; 09: 97
  • 14 Smith EE, Shobha N, Dai D. et al. Risk score for in-hospital ischaemic stroke mortality derived and validated within the get with the guidelines-stroke program. Circulation 2010; 122: 1496-1504.
  • 15 van Domburg RT, Meeter K, van Berkel DF. et al. Smoking cessation reduces mortality after coronary artery bypass surgery: a 20-year follow-up study. J Am Coll Cardiol 2000; 36: 878-883.
  • 16 Ali SF, Smith EE, Bhatt DL. et al. Paradoxical association of smoking with in-hospital mortality among patients admitted with acute ischaemic stroke. J Am Heart Assoc 2013; 02: e000171.
  • 17 Gurbel PA, Nolin TD, Tantry US. Clopidogrel efficacy and cigarette smoking status. J Am Med Assoc 2012; 307: 2495-2496.
  • 18 Bliden KP, Baker BA, Nolin TD. et al. Thienopyridine efficacy and cigarette smoking status. Am Heart J 2013; 165: 693-703.
  • 19 Gurbel PA, Bliden KP, Logan DK. et al. The Influence of Smoking Status on the Pharmacokinetics and Pharmacodynamics of Clopidogrel and Prasugrel: The PARADOX Study. J Am Coll Cardiol 2013; 62: 505-512.
  • 20 Zhao ZG, Chen M, Peng Y, Chai H. et al. The impact of smoking on clinical efficacy and pharmacodynamic effects of clopidogrel: a systematic review and meta-analysis. Heart. 2013 Epub ahead of print
  • 21 Huber K, Schrör K. High on-treatment platelet reactivity--why should we be concerned?. Thromb Haemost 2013; 109: 789-791.
  • 22 Dahlen JR, Price MJ, Parise H. et al. Evaluating the clinical usefulness of platelet function testing: considerations for the proper application and interpretation of performance measures. Thromb Haemost 2013; 109: 808-816.
  • 23 Cattaneo M. High on-treatment platelet reactiv-ity--definition and measurement. Thromb Haemost 2013; 109: 792-798.
  • 24 Park KW, Park JJ, Jeon KH. et al. Enhanced clopidogrel responsiveness in smokers: smokers’ paradox is dependent on cytochrome P450 CYP1A2 status. Arterioscler Thromb Vasc Biol 2011; 31: 665-671.
  • 25 Shanker G, Kontos JL, Eckman DM. et al. Nicotine upregulates the expression of P2Y12 on vascular cells and megakaryoblasts. J Thromb Thrombolysis 2006; 22: 213-220.
  • 26 Hochholzer W, Trenk D, Mega JL. et al. Impact of smoking on antiplatelet effect of clopidogrel and prasugrel after loading dose and on maintenance therapy. Am Heart J 2011; 162: 518-526. e5
  • 27 Cornel JH, Becker RC, Goodman SG. et al. Prior smoking status, clinical outcomes, and the comparison of ticagrelor with clopidogrel in acute coronary syndromes-insights from the PLATelet inhibition and patient Outcomes (PLATO) trial. Am Heart J 2012; 164: 334-342. e1
  • 28 Cornel JH, Ohman EM, Neely B. et al. Impact of smoking status on clinical outcomes with prasugrel versus clopidogrel in patients with acute coronary syndromes managed without revasculariz-ation: Insights from the TRILOGY ACS trial. J Am Coll Cardiol. 2013 61. A A39.
  • 29 Gurbel PA, Erlinge D, Ohman EM. et al. Platelet function during extended prasugrel and clopidogrel therapy for patients with ACS treated without revascularization. The TRILOGY ACS platelet function substudy. J Am Med Assoc 2012; 308: 1785-1794.
  • 30 Rubenstein D, Jesty J, Bluestein D. Differences between mainstream and sidestream cigarette smoke extracts and nicotine in the activation of platelets under static and flow conditions. Circulation 2004; 109: 78-83.
  • 31 Blache D. Involvement of hydrogen and lipid peroxides in acute tobacco smoking-induced platelet hyperactivity. Am J Physiol 1995; 268: H679-685.
  • 32 Lupia E, Bosco O, Goffi A. et al. Thrombopoietin contributes to enhanced platelet activation in cigarette smokers. Atherosclerosis 2010; 210: 314-319.
  • 33 Assinger A, Schmid W, Volf I. Decreased VASP phosphorylation in platelets of male and female smokers of young age. Platelets 2010; 21: 596-603.
  • 34 Della Corte A, Tamburrelli C, Crescente M. et al. Platelet proteome in healthy volunteers who smoke. Platelets 2012; 23: 91-105.
  • 35 Tuut M, Hense HW. Smoking, other risk factors and fibrinogen levels. evidence of effect modification. Ann Epidemiol 2001; 11: 232-238.
  • 36 Sinha S, Luben RN, Welch A. et al. Fibrinogen and cigarette smoking in men and women in the European Prospective Investigation into Cancer in Norfolk (EPIC-Norfolk) population. Eur J Cardiovasc Prev Rehabil 2005; 12: 144-150.
  • 37 Balleisen L, Bailey J, Epping PH. et al. Epidemiological study on factor VII, factor VIII and fibrinogen in an industrial population: I. Baseline data on the relation to age, gender, body-weight, smoking, alcohol, pill using, and menopause. Thromb Haemost 1985; 54: 475-479.
  • 38 Kannel WB, D’Agostino RB, Belanger AJ. Fibri-nogen, cigarette smoking, and risk of cardiovascular disease: insights from the Framingham Study. Am Heart J 1987; 113: 1006-1010.
  • 39 Frohlich M, Sund M, Lowel H. et al. Independent association of various smoking characteristics with markers of systemic inflammation in men. Results from a representative sample of the general population (MONICA Augsburg Survey 1994/95). Eur Heart J 2003; 24: 1365-1372.
  • 40 Mannucci PM. Recent progress in the pathophysiology of fibrinogen. Eur Heart J 1995; 16 A 25-30.
  • 41 Tappia PS, Troughton KL, Langley-Evans SC. et al. Cigarette smoking influences cytokine production and antioxidant defences. Clin Sci 1995; 88: 485-489.
  • 42 Barua RS, Sy F, Srikanth S. et al. Effects of cigarette smoke exposure on clot dynamics and fibrin structure: an ex vivo investigation. Arterioscler Thromb Vasc Biol 2010; 30: 75-79.