Case Report

Sirolimus-Induced Inflammatory Papules with Acquired Reactive Perforating Collagenosis
J. Lübbe^a, O. Sorg^a, P.-J. Malé^b, J.-H. Saurat^a, I. Masouyé<sup>a

a</sup>Clinique et Policlinique de Dermatologie et Vénéréologie et
^bClinique de Gastroentérologie, Hôpital Cantonal Universitaire de Genève, Geneva, Switzerland

Address of Corresponding Author

Dermatology 2008;216:239-242 (DOI: 10.1159/000112934)

  Key Words

• Sirolimus
• Dermatosis, perforating
• Follicular papules

  Abstract

Sirolimus is an immunosuppressive macrolide with antineoplasic properties that is increasingly used in posttransplantation immunosuppression. The treatment is frequently associated with cutaneous side effects such as sirolimus-associated acneiform facial dermatitis, which has been observed in up to 50% of treated patients. We report a 51-year-old female with liver transplantation who developed inflammatory papules and nodules on the face and the upper chest 3 weeks after the initiation of sirolimus therapy. Sequential biopsies revealed lymphocytic infiltration of the dermis with a peculiar pattern of sebotropism, while older lesions showed acquired reactive perforating collagenosis. The lesions were responsive to hydroxychloroquine treatment despite continued sirolimus treatment.

Copyright © 2008 S. Karger AG, Basel

  Author Contacts

Dr. Jann Lübbe, PD
Dermatologie HUG
CH-1211 Genève 14 (Switzerland)
Tel. +41 22 37 28 998, Fax +41 22 37 29 470
E-Mail jann.lubbe@hcuge.ch

  Article Information

Received: July 5, 2007
Accepted: August 29, 2007
Published online: January 9, 2008
Number of Print Pages : 4
Number of Figures : 2, Number of Tables : 0, Number of References : 28