Pharmacology

Applications of a Blood-Brain Barrier Technology Platform to Predict CNS Penetration of Various Chemotherapeutic Agents. 2. Cationic Peptide Vectors for Brain Delivery
M. Adenot, P. Merida, R. Lahana

Synt:em, Nîmes, France

Address of Corresponding Author

Chemotherapy 2007;53:73-76 (DOI: 10.1159/000098422)

  Key Words

• Blood-brain barrier
• Transcytosis
• Cationic peptides
• Brain delivery

  Abstract

Background: SynB family peptides conjugated to several drugs have been shown to increase the brain uptake and in vivo activities of these drugs via an adsorptive-mediated transcytosis mechanism. Based on both in vivo and in vitro experimental data, a cell uptake component has been added to our computational model of blood-brain barrier. Methods: In situ brain perfusion, in vitro cell model and a computational cell uptake model have been used to discover brain-penetrating properties of SynB peptides and to screen libraries of new rationally designed peptide vectors suitable for brain drug delivery. Results and Conclusion: Starting from small peptide vectors that enhance the brain transport coefficient, the BBB platform has made it possible to design libraries of peptide vectors with enhanced transport properties.

Copyright © 2007 S. Karger AG, Basel

  Author Contacts

Marc Adenot, MD
8, rue des alouettes
FR-69008 Lyon (France)
Tel. +33 04 37 90 06 58, E-Mail marc.adenot@voila.fr

  Article Information

Presented at the 1st World Conference on Magic Bullets - EHRLICH 2004, Nürnberg, Germany, September 9-11, 2004.

Received: January 24, 2005
Accepted after revision: January 17, 2006
Published online: January 3, 2007
Number of Print Pages : 4
Number of Figures : 3, Number of Tables : 0, Number of References : 5