Case Report · Kasuistik

Rationale for Individualized Therapy in Sinonasal Teratocarcinosarcoma (SNTC): Case Report
M. Nitsche^a; R.M. Hermann^a; H. Christiansen^a; J. Berger^b; O. Pradier^a

^aDepartment of Radiotherapy, University of Göttingen, ^bDepartment of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Göttingen, Germany

Onkologie 2005;28:653-656
(DOI: 10.1159/000089146)

  Summary

Background: Sinonasal Teratocarcinosarcoma (SNTC) is a very unusual and aggressive neoplasm characterized by the combination of malignant teratoma and carcinosarcoma features. We present the first case of malignant SNTC treated with individualized multimodal therapy including a histology-specific chemotherapy. Case Report: A 31-year-old man presented with an obstruction of the right pansinus. Histology showed an SNTC with major parts of small cell, poorly differentiated carcinoma and a small proportion of highly differentiated embryonal rhabdomyosarcoma. An operation was performed followed by intraoperative application of a 5-FU ointment. Adjuvant chemotherapy with cisplatin, etoposid and ifosfamid were given in regard to the major components of this heterogeneous tumor. Radiotherapy up to 59.4 Gy was applied. Conclusion: 36 months after the end of therapy, there is no sign of tumor recurrence or metastasis in our patient. We suggest that surgery, radiotherapy and a histology-specific multidrug chemotherapy seems to be a therapeutic approach that is appropriate for this heterogeneous tumor.

Copyright © 2005 S. Karger GmbH, Freiburg