Address of Corresponding Author

Int Arch Allergy Immunol 2005;138:324-327 (DOI: 10.1159/000088871)

  Key Words

• Animal allergens
• Contact urticaria
• Giraffe
• Occupational allergy

  Abstract

Background: Immediate-type hypersensitivity to animal proteins is a common problem in people occupationally exposed to animals. Methods: A 19-year-old female working as a voluntary zookeeper in her off-time suffered from hives on her forearms following contact to the fur of a giraffe. For diagnostic evaluation, skin prick tests, assessment of specific serum IgE antibodies, and basophil activation tests were performed. Results: Skin prick tests with a standard series of common aeroallergens were positive for various pollens. Prick testing with native materials was positive for extracts of hair from two different giraffe subspecies in the patient, but not in control subjects. By CAP-FEIA, no specific serum IgE antibodies to dander of a large variety of animals were found in the patient. In the basophil activation test, expression of the activation marker CD63 was induced by extract of giraffe hair on the cells from the patient, but not on those from unaffected controls. Conclusions: This patient suffers from an 'exotic' immediate-type contact allergy to giraffe hair.

Copyright © 2005 S. Karger AG, Basel

  Author Contacts

Correspondence to: Dr. med. Thomas Herzinger
Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig-Maximilians-Universität
Frauenlobstrasse 9-11, DE-80337 Munich (Germany)
Tel. +49 89 5160 6388, Fax +49 89 5160 6389
E-Mail Thomas.Herzinger@lrz.uni-muenchen.de

  Article Information

Received: January 27, 2005
Accepted after revision: July 7, 2005
Published online: October 13, 2005
Number of Print Pages : 4
Number of Figures : 2, Number of Tables : 0, Number of References : 18