Address of Corresponding Author

Eur Neurol 2005;54:1-9 (DOI: 10.1159/000086754)

  Key Words

• Progressive supranuclear palsy
• Neuropathology
• Postmortem
• Brain donors

  Abstract

Progressive supranuclear palsy (PSP) is the second most common parkinsonian syndrome, characterized by a 'diverse' clinical phenotype. Although several different diagnostic guidelines have been proposed, the early and accurate diagnosis of PSP remains problematic and neuropathology is still considered the 'gold standard'. In order to contribute to the better clinical characterization of PSP, we conducted a postmortem study in a cohort of 22 consecutive PSP brain donors and compared our results with those of previously published reports. Our results further demonstrate and expand the varied clinical picture of PSP. Furthermore, we report associations between older age at onset, early dementia, early falls and smoking with shorter PSP duration.

Copyright © 2005 S. Karger AG, Basel

  Author Contacts

Spiridon Papapetropoulos, MD, PhD
Department of Neurology
University of Miami, School of Medicine, Room 4004
1501 NW 9th Avenue, Miami, FL 33136 (USA)
Tel. +1 305 243 8461, Fax +1 305 243 3649, E-Mail spapapetropoulos@med.miami.edu

  Article Information

Received: December 15, 2004
Accepted: April 4, 2005
Published online: July 5, 2005
Number of Print Pages : 9
Number of Figures : 0, Number of Tables : 2, Number of References : 61