Association between Angiotensin-Converting Enzyme Gene Polymorphism and Alzheimer’s Disease in a Chinese Population

Vol. 20, No. 1, 2005

Free Abstract Article (References) Article (PDF 119 KB)

Original Research Article

Association between Angiotensin-Converting Enzyme Gene Polymorphism and Alzheimer's Disease in a Chinese Population
Jun-Wu Zhang^a, Xiao-Qing Li^a, Zhen-Xin Zhang^b, Deng Chen^a, Hua-Lu Zhao^a, Ya-Ning Wu^a, Qiu-Ming Qu^c

^aNational Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences,
^bDepartment of Neurology, Peking Union Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, and
^cDepartment of Neurology, the First Affiliated Hospital, Xi'an Medical University, Xi'an, Shaanxi Province, China

Address of Corresponding Author

Dement Geriatr Cogn Disord 2005;20:52-56 (DOI: 10.1159/000085075)

Key Words

Alzheimer's disease
Angiotensin-converting enzyme
DCP1 polymorphism
Risk factor

Abstract

Angiotensin-converting enzyme has shown altered activity in patients with neurological diseases. An insertion/deletion (I/D) polymorphism of the DCP1 gene encoding angiotensin-converting enzyme has been reported to be associated with the risk for Alzheimer's disease (AD), but ambiguous results have also been presented. We conducted a case-control study in a sample composed of 192 sporadic AD patients and 195 age- and sex-matched controls from Chinese Han population in Beijing and Xi'an districts to investigate the possible effect of the polymorphism. Our data revealed no association between the DCP1 polymorphism and AD risk in the total sample. There was no significant difference in the DCP1 allele or genotype frequencies between cases and controls when stratified by gender and APOE ε4 status. However, the D allele and D/D genotype were more frequent among AD patients between 66 and 70 years compared with controls (D allele: OR = 2.8, 95% CI = 1.5-5.2, p = 0.001; D/D genotype: OR = 5.9, 95% CI = 1.7-19.9, p = 0.002). Our results provided new proof that the DCP1 D allele was a probable risk factor for late-onset AD. Its role was independent and was limited to the population at a certain age.

Author Contacts

Prof. Dr. Jun-Wu Zhang
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences
Chinese Academy of Medical Sciences and Peking Union Medical College
Beijing 100005 (China)
Tel. +86 10 65296423, Fax +86 10 65240529, E-Mail junwu_zhang@pumc.edu.cn

Article Information

Accepted: January 21, 2005
Published online: April 12, 2005
Number of Print Pages : 5
Number of Figures : 0, Number of Tables : 1, Number of References : 28

Medline Abstract (ID 15832037)

Download Citation

Cited In

This journal is part of the first subject package of the Karger

Journal Archive Collection

Information on packages (PDF)
Free sample issues

For non-native English speakers and international authors who would like assistance with their writing before submission, we suggest American Journal Experts for their research paper editing service.