CpG Motifs as Possible Adjuvants for the Treatment of Allergic Diseases

Vol. 129, No. 3, 2002

Free Abstract Article (Fulltext) Article (PDF 77 KB)

Review

CpG Motifs as Possible Adjuvants for the Treatment of Allergic Diseases
Barbara Bohle

Department of Pathophysiology, Division of Immunopathology, University of Vienna, Vienna, Austria

Address of Corresponding Author

Int Arch Allergy Immunol 2002;129:198-203 (DOI: 10.1159/000066771)

Key Words

CpG motif
Type I allergy
Specific immunotherapy
Th1/Th2
Immunomodulation

Abstract

DNA containing unmethylated CpG motifs and synthetic oligodeoxynucleotides derived thereof (CpG ODN) have intensively been investigated for their immunostimulatory properties in the recent past. CpG ODN were shown to induce strong Th1 immune responses in mammals. The downregulation of the antigen-driven Th2 response of type I allergies represents one important therapeutic goal of specific immunotherapy (SIT). Hence, CpG ODN represent promising substances which support the modification of the pathogenic Th2 immune profile toward a Th1 profile when used as adjuvants for SIT. This article discusses how the use of CpG ODN in immunotherapeutics could improve the treatment of type I allergy.

Author Contacts

Correspondence to: Dr. Barbara Bohle
Department of Pathophysiology, Division of Immunopathology
University of Vienna, AKH-3Q
Währinger Gürtel 18-20, A-1090 Vienna (Austria)
Tel. +43 1 40400 5101, Fax +43 1 40400 5130, E-Mail barbara.bohle@akh-wien.ac.at

Article Information

Number of Figures : 1, Number of Tables : 0, Number of References : 65

Medline Abstract (ID 12444316)

Download Citation

For non-native English speakers and international authors who would like assistance with their writing before submission, we suggest American Journal Experts for their research paper editing service.