Hereditary pancreatitis: A model for understanding the genetic basis of acute and chronic pancreatitis

doi:10.1159/000055864

Pancreatology

Volume 1, Issue 6, 2001, Pages 566-571

https://doi.org/10.1159/000055864 Get rights and content

Abstract

Progress in understanding pancreatic diseases has been limited by a number of factors. Primary problems include the absence of good animal models, and difficulty in understanding the origin of pancreatic disease since the disease is usually manifest by the progressive destruction of the gland itself. Beginning in 1995, our laboratory, with the support of the Midwest Multicenter Pancreatic Study Group, began investigating the genetic basis of hereditary pancreatitis. Utilization of information becoming available through the human genome project allowed us to map and identify the hereditary pancreatitis gene as cationic trypsinogen (PRSS1). Molecular modeling, and subsequent experimental evidence, has solved key elements of the mysteries surrounding the origin of acute pancreatitis and the progression of acute pancreatitis to chronic pancreatitis. The availability of new genetic information and genomic tools should produce a revolution in our understanding of pancreatic diseases.

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^*: Based on a lecture at the combined meeting of the International Association of Pancreatology and the American Pancreatic Association, Chicago, 2000.

^a: David Whitcomb, MD, PhD, Division of Gastroenterology, Hepatology and Nutrition, Center for Genomic Sciences University of Pittsburgh Medical Center, Mezzanine Level, C Wing, PUH 200 Lothrop Street, Pittsburgh, PA 15213 (USA) Tel. +1 412 648 9604, Fax +1 412 383 7236

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Hereditary pancreatitis: A model for understanding the genetic basis of acute and chronic pancreatitis*

Abstract

Gastroenterology

Gastroenterology

Baillière's Clinical Gastroenterol

Gastroenterol Clin N Am

Med Clin N Am

Med Clin N Am

Gastroenterology

Genomics

Biochem Biophys Acta

Biochem Biophys Acta

J Biol Chem

Gastroenterology

Gastroenterology

Gastroenterology

Gastroenterology

Gastroenterology