Short-Term Rivastigmine Treatment Reduces EEG Slow-Wave Power in Alzheimer Patients

Vol. 43, No. 4, 2001

Free Abstract Article (References) Article (PDF 155 KB)

Pharmacoelectroencephalography. Main Editor: W.M. Herrmann (Berlin) / Original Paper

Short-Term Rivastigmine Treatment Reduces EEG Slow-Wave Power in Alzheimer Patients
Georg Adler, Stefanie Brassen

Day Clinic for the Elderly and Clinical Neurophysiology Service, Central Institute of Mental Health, Mannheim, Germany

Address of Corresponding Author

Neuropsychobiology 2001;43:273-276 (DOI: 10.1159/000054902)

Key Words

EEG
Dementia
Alzheimer's disease
Therapy
Acetylcholinesterase inhibitor
Rivastigmine

Abstract

The effects of a 5-day treatment with rivastigmine on the resting EEG power spectrum were studied in 15 mildly to moderately ill Alzheimer patients. In these patients, beta power was positively correlated with cognitive performance and negatively correlated with functional impairment. Rivastigmine produced a decrease in delta and theta power with no effect of hemisphere and electrode position. Delta power decrease reflects the cerebral cholinergic action of rivastigmine and may thus allow a quantitative assessment of its CNS effects.

Author Contacts

Priv.-Doz. Dr. Georg Adler
Zentralinstitut für Seelische Gesundheit, Postfach 12 21 20
D-68072 Mannheim (Germany)
Tel. +49 621 1703 792, Fax +49 621 2 34 29
E-Mail adler@as200.zi-mannheim.de

Article Information

Number of Print Pages : 4
Number of Figures : 2, Number of Tables : 0, Number of References : 33

Medline Abstract (ID 11340368)

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