Allergy in the 21st Century: New Answers to Old Questions
23rd Symposium of the Collegium Internationale Allergologicum
May 18-23, 2000, Hakone, Japan
Editors: Takeru Ishikawa, Kumamoto; Terumasa Miyamoto, Tokyo; Hirokazu Okudaira, Tokyo; Hisao Tomioka, Chiba; Rudolf Valenta, Vienna; Dietrich Kraft, Vienna

Eosinophils, Monocytes and Macrophages

Role of Apoptosis in Atopic Dermatitis
Axel Trautmann, Mübeccel Akdis, Sven Klunker, Kurt Blaser, Cezmi A. Akdis

Swiss Institute of Allergy and Asthma Research (SIAF), Davos, Switzerland

Address of Corresponding Author

Int Arch Allergy Immunol 2001;124:230-232 (DOI: 10.1159/000053720)

  Key Words

• Apoptosis
• Keratinocyte
• Eosinophil
• T cell
• Atopic dermatitis
• Eczema

  Abstract

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Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disease characterized by typically distributed eczematous skin lesions [1]. The majority of AD patients show very high serum levels of total and allergen-specific IgE and activation of peripheral blood T cells and their preferential secretion of type 2 T cell cytokines was repeatedly reported [2, 3, 4, 5]. In AD, the pivotal role of CD45RO+ (memory/effector) T cells expressing the skin homing receptor, the cutaneous lymphocyte-associated antigen (CLA), was demonstrated [6]. CLA+ T cells in AD represent an in vivo activated memory/effector cell subset retaining allergen specificity [3, 4, 5]. Both CD4+ and CD8+ CLA+ T cells express increased surface activation markers, contain and spontaneously release preformed cytokines, mainly IL-5 and IL-13 and to a low extent IL-4 and IFN- in comparison to the CLA- subset [3, 4, 5].

Copyright © 2001 S. Karger AG, Basel

  Author Contacts

Correspondence to: Dr. Axel Trautmann
Swiss Institute of Allergy and Asthma Research (SIAF)
Obere Strasse 22
CH-7270 Davos (Switzerland)
Tel. +41 81 410 08 48, Fax +41 81 410 08 40, E-Mail akdisac@siaf.unizh.ch

  Article Information

Number of Print Pages : 3
Number of Figures : 1, Number of Tables : 0, Number of References : 13