Allergy in the 21st Century: New Answers to Old Questions
23rd Symposium of the Collegium Internationale Allergologicum
May 18-23, 2000, Hakone, Japan
Editors: Takeru Ishikawa, Kumamoto; Terumasa Miyamoto, Tokyo; Hirokazu Okudaira, Tokyo; Hisao Tomioka, Chiba; Rudolf Valenta, Vienna; Dietrich Kraft, Vienna

Regulatory Pathways

Histamine Upregulates Th1 and Downregulates Th2 Responses due to Different Patterns of Surface Histamine 1 and 2 Receptor Expression
M. Jutel^a, S. Klunker^b, M. Akdis^b, J. Maolepszy^b, Oliver A.R. Thomet^b, T. ak-Nejmark^a, K. Blaser^b, C.A. Akdis<sup>b

a</sup>Wrocaw University of Medicine, Wrocaw, Poland;
^bSwiss Institute of Allergy and Asthma Research, Davos, Switzerland

Address of Corresponding Author

Int Arch Allergy Immunol 2001;124:190-192 (DOI: 10.1159/000053707)

  Key Words

• T cell subsets
• Receptors
• Histamine

  Abstract

Histamine, which acts via G protein-coupled receptors, is an important mediator of immediate hypersensitivity and is also able to influence the nature of T cell responses. We demonstrated that TH1 and Th2 cells express distinct surface histamine receptor patterns and that Th1-type responses are enhanced by histamine, whereas Th2-type responses are negatively regulated, due to different intracellular signals generated by histamine stimulation. These findings account for negative feedback regulation in a wide variety of pathologies.

Copyright © 2001 S. Karger AG, Basel

  Author Contacts

Correspondence to: Dr. Marek Jutel
Department of Internal Medicine and Allergy
Wrocaw University of Medicine, Traugutta 57
PL-50-417 Wroclaw (Poland)
Tel. +48 71 344 2264, Fax +48 71 370 0129, E-Mail mjutel@dilnet.wroc.pl

  Article Information

Number of Print Pages : 3
Number of Figures : 1, Number of Tables : 0, Number of References : 17