Short Communication

Improved Power of Sib-Pair Linkage Analysis Using Measures of Complex Trait Dynamics
Jason H. Moore

Program in Human Genetics, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, Tenn., USA

Address of Corresponding Author

Hum Hered 2001;52:113-115 (DOI: 10.1159/000053363)

  Key Words

• Linkage analysis
• Power
• Complex traits
• Epistasis
• Nonlinear dynamics

  Abstract

The influence of epistasis on a quantitative trait can reduce the power of linkage analysis to identify the underlying loci. In the present study, we simulated a complex trait derived from a dynamic one-locus gene expression system with epistasis arising from feedback regulation and tested the power of sib-pair linkage analysis methods for detecting the underlying quantitative trait locus (QTL). Using this simple genetic architecture, we demonstrate that the power of sib-pair linkage analysis can be greatly improved if measures of complex trait dynamics are considered.

Copyright © 2001 S. Karger AG, Basel

  Author Contacts

Jason H. Moore, PhD
Program in Human Genetics, Department of Molecular Physiology and Biophysics
519 Light Hall, Vanderbilt University Medical School
Nashville, TN 37232-0700 (USA)
Tel. +1 615 343 5852, Fax +1 615 343 8619, E-Mail moore@phg.mc.vanderbilt.edu

  Article Information

Received: Received: January 2000
Accepted: October 2000
Revision received: July 2000
Number of Print Pages : 3
Number of Figures : 0, Number of Tables : 3, Number of References : 13