Original Paper

Relationship between Polymorphism in the Angiotensinogen, Angiotensin-Converting Enzyme or Angiotensin II Receptor and Renal Progression in Japanese NIDDM Patients
Yasuhiko Tomino^a, Yuichiro Makita^a, Toshihide Shike^a, Tomohito Gohda^a, Masakazu Haneda^b, Ryuichi Kikkawa^b, Tsuyoshi Watanabe^c, Tsuneharu Baba^d, Hiroaki Yoshida<sup>e

a</sup>Division of Nephrology, Department of Medicine, Juntendo University School of Medicine, Tokyo,
^bShiga University of Medical Science, Shiga,
^cFukushima Medical College, Fukushima,
^dTokyo University,
^eTokyo Jikeikai Medical College, Tokyo, Japan

Address of Corresponding Author

Nephron 1999;82:139-144 (DOI: 10.1159/000045390)

  Key Words

• Gene polymorphism
• Renin-angiotensin system
• Renal progression
• Diabetic nephropathy

  Abstract

We determined the relationship between the gene polymorphism of angiotensinogen (AGT), angiotensin-converting enzyme (ACE), or angiotensin II receptor (AT1R) and the progression of diabetic nephropathy in a multicenter trial of ethnically homogeneous Japanese patients with non-insulin-dependent diabetes (NIDDM). Gene polymorphism of ACE I/D, AGT M235T and AT1R A1166C was determined by polymerase chain reaction amplification using allele-specific primers. Japanese NIDDM patients (n = 1,152) were selected from several diabetic clinics. All patients were divided into three groups as follows: (1) group I (n = 407): normoalbuminuric patients; (2) group II (n = 327): microalbuminuric patients, and (3) group III (n = 418): overt albuminuric patients. Clinical factors for investigation in all patients were the date of birth, gender, levels of urinary albumin excretion, findings of the ocular fundus, duration of diabetes, hemoglobin A1c and blood pressure. It appears that genetic polymorphisms in the renin-angiotensin systems, i.e. ACE or AT1R, may affect the progression to renal failure of patients (especially females) with NIDDM.

  Author Contacts

Yasuhiko Tomino, MD, Professor
Division of Nephrology, Department of Medicine
Juntendo University School of Medicine
Tokyo 113-8421 (Japan)
Tel./Fax +81 3 5802 1064, E-Mail yasu@med.juntendo.ac.jp

  Article Information

Received: Accepted: January 15, 1999
Number of Print Pages : 6
Number of Figures : 3, Number of Tables : 2, Number of References : 42