Haptoglobin Phenotypes in HIV-1-Seropositive Patients in Ghana: Decreased Risk for Hp0 Individuals

Vol. 50, No. 6, 2000

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Short Communication

Haptoglobin Phenotypes in HIV-1-Seropositive Patients in Ghana: Decreased Risk for Hp0 Individuals
I.K.E. Quaye, F.A. Ekuban, J.A.M. Brandful, B.A. Gyan, B.D. Akanmori, N.-A. Ankrah

Noguchi Memorial Institute for Medical Research University of Ghana, Legon, Accra, Ghana

Address of Corresponding Author

Hum Hered 2000;50:382-383 (DOI: 10.1159/000022944)

Key Words

Haptoglobin polymorphism
HIV-1
Ghanaians

Abstract

Plasma haptoglobin phenotypes were determined by polyacrylamide gel electrophoresis, followed by benzidine staining for 58 HIV-1 seropositive Ghanaians and 79 randomly selected age-matched controls. Hp0 was present in only 14% of HIV-1 seropositive individuals compared with more than 40% of the controls. The Hp0 individuals showed a highly significant reduced risk for HIV-1 infection (OR = 0.21, 95% CI = 0.09-0.51, p = 0.0002). Hp0 may have a protective effect in HIV-1 infection.

Author Contacts

Dr. Isaac K.E. Quaye
Noguchi Memorial Institute for Medical Research
PO Box LG 581, University of Ghana, Legon
Accra (Ghana)
Tel. +233 21 501178/9, Fax +233 21 502 182, E-Mail noguchi@ncs.com.gh

Article Information

Received: Received: March 8, 1999
Revision accepted: September 3, 1999
Accepted: September 9, 1999
Number of Print Pages : 2
Number of Figures : 0, Number of Tables : 1, Number of References : 16

Medline Abstract (ID 10899757)

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