Original Paper

Low-Order Polynomial Trends of Female-to-Male Map Distance Ratios along Human Chromosomes
Wentian Li^a, Cathy S.J. Fann^b, Jürg Ott<sup>a

a</sup> Rockefeller University, New York, N.Y.,
^b Division of Epidemiology and Statistics, Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, Bronx, N.Y., USA

Address of Corresponding Author

Hum Hered 1998;48:266-270 (DOI: 10.1159/000022814)

  Key Words

• Recombination fraction
• Map distance
• Human chromosomes

  Abstract

Recombination rates in humans tend to be sex specific. For a given map interval delimited by genetic markers, the difference between male and female recombination rates may be measured by the ratio, R, of female-to-male map distance. On average over all chromosomes, R is close to 2, but this ratio is region specific. The spatial variation of R can be captured by a low-order (linear, quadratic, etc.) trend across the length of the chromosome. Chromosome maps have been constructed that take into account such trends. Resulting map distances tend to be more accurate than when such trends are ignored. These maps may be obtained at URL ftp://linkage.rockefeller.edu/SexSpecMaps/.

  Author Contacts

Dr. Jürg Ott
Rockefeller University, Box 192
1230 York Avenue, New York, NY 10021 (USA)
Tel. +1 212 327 7991, Fax +1 212 327 7996
E-Mail ott@rockefeller.edu

  Article Information

Received: Received: February 20, 1998
Accepted: April 22, 1998
Revision received: April 17, 1998
Number of Print Pages : 5
Number of Figures : 1, Number of Tables : 1, Number of References : 14