Effects of Three Cytokine Regimens on Hematologic Recovery and Progenitor Cell Mobilization after High-Dose Cyclophosphamide, Etoposide, and Cisplatin

Vol. 59, No. 1, 2000

Free Abstract Article (Fulltext) Article (PDF 313 KB)

Clinical Study

Effects of Three Cytokine Regimens on Hematologic Recovery and Progenitor Cell Mobilization after High-Dose Cyclophosphamide, Etoposide, and Cisplatin
A. Ballestrero^a, F. Ferrando^a, A. Garuti^a, R. Gonella^a, P. Stura^a, M. Sessarego^a, D. Amoroso^b, F. Boccardo^b, F. Patrone^a

^aDipartimento di Medicine Interna, Università di Genova;
^bIstituto Nazionale per la Ricerca sul Cancro, Genova, Italia

Address of Corresponding Author

Oncology 2000;59:7-13 (DOI: 10.1159/000012129)

Key Words

High-dose chemotherapy
Growth factors
Hematopoietic progenitors
G-CSF
GM-CSF
Interleukin-3

Abstract

The aim of this study was to compare both the effects on hematologic recovery and circulating progenitor cell mobilization and the toxicity of three cytokine regimens administered after high-dose non-myeloablative chemotherapy with cyclophosphamide 5 g/m², etoposide 1.5 g/m² and cisplatin 150 mg/m². Thirty-five consecutive patients were non-random sequentially allocated to one of three treatment groups: (1) granulocyte colony-stimulating factor alone (n = 15); (2) granulocyte-macrophage colony-stimulating factor alone (n = 10), and (3) sequential interleukin-3 and granulocyte-macrophage colony-stimulating factor (n = 10). Neutrophil recovery in group 1 was significantly hastened as compared to the two other groups (median 2 days, p < 0.005), while no significant differences were observed between groups 2 and 3. CD34+ cells peaked about 2 days earlier in group 1 compared to the other groups (p = 0.0001), whereas the median peak value of CD34+ cells was similar in the three groups. In all patients, the toxicity related to cytokine administration was low and easily manageable with nonsteroidal anti-inflammatory drugs.

Author Contacts

Prof. Franco Patrone
Dipartimento di Medicina Interna, Università di Genova
Viale Benedetto XV no. 6, I-16132 Genova (Italia)
Tel. +39 010 3538952, Fax +39 010 3538650
E-Mail fpatrone@unige.it

Article Information

Number of Print Pages : 7
Number of Figures : 1, Number of Tables : 3, Number of References : 30

Medline Abstract (ID 10895059)

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