Polymorphisms of the Parkin Gene in Sporadic Parkinson’s Disease among Chinese in Taiwan

Vol. 44, No. 2, 2000

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Original Paper

Polymorphisms of the Parkin Gene in Sporadic Parkinson's Disease among Chinese in Taiwan
Chaur-Jong Hu^a, Shing-Ming Sung^b, Hsing-Cheng Liu^b, Cheng-Chun Lee^c, Chang-Hai Tsai^c, Jan-Gowth Chang^c

^aDepartment of Neurology, Taipei Municipal Jen-Ai Hospital,
^bTaipei City Psychiatry Center, Taipei, and
^cDivision of Molecular Medicine, Department of Medical Research, China Medical College Hospital, Taichung, Taiwan

Address of Corresponding Author

Eur Neurol 2000;44:90-93 (DOI: 10.1159/000008203)

Key Words

Parkinson's disease
Parkin gene
Polymorphism
Chinese
Taiwan

Abstract

The role of genetics in Parkinson's disease (PD), previously controversial, is now documented by several studies. A major breakthrough has been the discovery of two single-gene defects in familial PD. A single base pair change at position 209 from G to A (G209A) in the fourth exon of the alpha -synuclein gene has been identified in cases of autosomal dominant familial PD. Mutations in the Parkin gene can induce autosomal recessive juvenile parkinsonism. A polymorphism of R/W366 in the Parkin gene was found to be associated with a protective factor for sporadic PD. We surveyed the polymorphisms of the Parkin gene, including S/N167, R/W366 and V/L380, in 92 cases of sporadic PD and 98 nonaffected individuals in Taiwanese Chinese. The allele frequencies of these polymorphisms are not significantly different between PD and nonaffected controls. We conclude that polymorphisms of the Parkin gene, S/N167, R/W366, V/L380, are not genetic factors for sporadic PD among Chinese in Taiwan.

Author Contacts

Dr. Jan-Gowth Chang
Department of Medical Research, Division of Molecular Medicine
China Medical College Hospital, 2, Yuh Der Road
Taichung 400 (Taiwan)
Tel. +886 4 2052121, ext. 1565, Fax +866 4 2033295

Article Information

Received: Received: November 15, 1999
Accepted: February 11, 2000
Number of Print Pages : 4
Number of Figures : 1, Number of Tables : 2, Number of References : 22

Medline Abstract (ID 10965160)

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