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Cigarette Smoking and Survival after Ovarian Cancer Diagnosis

¹ Queensland Institute of Medical Research and ² School of Population Health, University of Queensland, Brisbane, Queensland, Australia

Requests for reprints: Christina M. Nagle, Cancer and Population Studies Group, Queensland Institute of Medical Research, P.O. Box Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia. Phone: 61-7-3845-3540; Fax: 61-7-3362-0111. E-mail Christina.Nagle{at}qimr.edu.au

We have examined the association between cigarette smoking and ovarian cancer survival in 676 women with invasive epithelial ovarian cancer, recruited into a case-control study in the early 1990s. Information about cigarette smoking and other personal and reproductive factors was obtained from a personal interview at the time of diagnosis. Cox proportional hazards models were used to evaluate the association between cigarette smoking and time to ovarian cancer death. Current smokers at diagnosis were more likely to die early than women who had never smoked [adjusted hazard ratio (HR), 1.36; 95% confidence interval (95% CI), 1.01-1.84]. Increased risks of dying were greater among those who had accumulated more pack-years of smoking (HR for 30+ pack-years compared with never smokers, 1.94; 95% CI, 1.41-2.66) and smoked more cigarettes per day (HR, 1.93; 95% CI, 1.37-2.73). All these associations were stronger among women with late-stage disease (HR for current versus never smokers, 1.58; 95% CI, 1.15-2.18). Time since quitting had little effect on survival after adjusting for lifetime smoking exposure. These results validate and extend recent findings and suggest that premorbid cigarette smoking is related to worse outcome in ovarian cancer patients. (Cancer Epidemiol Biomarkers Prev 2006;15(12):2557–60)